Clinical manifestations of lactic acidosis

Lactic acid bacteria are the final product of anaerobic fermentation of glucose. Under normal circumstances, the lactic acid bacteria produced during the body's metabolism is oxidized and utilized in the liver, and the concentration of lactic acid bacteria does not exceed 1.8 mmol/L. When various reasons cause the blood lactate level to rise and cause metabolic acidosis, it is called lactic acid metabolic acidosis. Lactic acid bacteria metabolic acidosis that occurs essentially in diabetes is called diabetic lactic acid bacteria metabolic acidosis. So, what are the clinical symptoms of lactic acidosis?

Symptoms of lactic acidosis

1. Specific manifestations

Take a deep, deep breath (Kussmaul inhale). In metabolic acidosis, due to the increase in H2 concentration, the carotid body chemoeffector reflex is stimulated to stimulate the respiratory center, which increases the depth and frequency of inhalation, resulting in increased CO2 excretion and reduced blood HCO3- concentration. The ratio of (HCO3-) to (H2CO3) is close to 20:1, and the pH value can be maintained within the normal range. The compensation function of the respiratory tract is extremely fast, and deep and rapid breathing can usually occur within a few minutes.

Different levels of consciousness disorders. Lactic acidosis is a type of respiratory metabolic acidosis, which may be combined with inspiratory alkali poisoning due to deep and rapid breathing. Patients may have varying degrees of consciousness disorders such as mental disorder, trance, constant sleepiness, and even coma.

Vomiting Nonspecific lower abdominal pain. In lactic acidosis, due to the increase in H2O concentration, the sympathetic nerves in the digestive tract are stimulated, resulting in increased sympathetic humoral regulation, faster gastrointestinal smooth muscle motility, increased muscle spasm, and the patient may experience vomiting and nonspecific lower abdominal pain.

2. Primary and secondary main manifestations.

Laziness, tiredness, weakness, diarrhea, palpitations, and convulsions.

Causes of Lactic Acidosis

1. Insufficient oxygen. When the body is deprived of oxygen, the conversion of lactic acid bacteria will continue to increase.

2. Use of therapeutic drugs. The use of aldehyde drugs such as biguanides, sorbitol, maltitol, ethanol, alcohol, paracetamol and sodium salicylate can all cause lactic acid accumulation in the body.

3. Targeted diseases. It is common in diabetes, malignant tumors (sepsis, etc.), liver disease (subacute viral infection or toxic hepatitis with drug efficacy decline), more serious infection (sepsis, etc.), uremia, convulsions, pancreatitis and gastrointestinal diseases, etc. Targeted diseases often cause liver and kidney dysfunction, resulting in the body's unnecessary lactic acid bacteria being unable to be metabolized and excreted from the body, causing lactic acid accumulation.

4. Abnormalities in congenital metabolism. People with congenital glucose 6-phosphatase deficiency (type 1 glycogen storage disease) and oxidative phosphorylation deficiency may have abnormal lactic acid metabolism in the body, leading to metabolic acidosis.