High osteoclast index

When it comes to human growth and development, bones play an important role. You should know that a person's height is directly determined by the length of the bones, so the health of the bones is very important. Among them, osteoclasts are the main functional cells of bone absorption and play an important role in the development, growth, repair and reconstruction of bones, especially interacting with osteoblasts. Of course, there is a certain coefficient between the two. So, let’s talk about why the osteoclast index is high.

Osteoclasts are known for their bone resorption function. Furthermore, as a component of bone tissue, it performs the function of bone resorption. Osteoclasts correspond to osteoblasts (also called bone-forming cells) in function. The two work together and play an important role in the development and formation of bones. Highly expressed tartrate resistant acid phosphatase and cathepsin K are the main markers of osteoclasts.

But in addition to this, osteoclasts also have other biological functions. As of July 2018, the discoveries include the hematopoietic regulatory effect, bone formation regulatory effect, intraosseous angiogenesis regulatory effect, and the hormonal effect of osteocalcin. Osteoclasts have special absorption functions, and macrophages are also involved in the bone absorption process in certain local inflammatory lesions.

They are mainly distributed on the surface of bones. They are large multinucleated cells and their number is far less than that of osteoblasts. They are mostly located in the pits formed where bone tissue is absorbed. Osteoclasts have a special absorption function and can absorb organic matter and minerals from the bone matrix. Osteoclasts first secrete and release acidic ions to the local bone tissue that needs to be eliminated, dissolve inorganic minerals, and discharge them into the blood. The loss of inorganic matter exposes the collagen fibers in the bone matrix, and osteoclasts secrete proteinases to dissolve the organic matter in the bone tissue. Through these two basic steps, osteoclasts degrade bone matrix and dissolve and absorb calcium ions, which are then transferred into the blood, resulting in osteoclastogenesis.

Generally speaking, there are osteoclasts that break down bones and osteoblasts that form bones in the body, and the functions of the two types of cells in the human body maintain a good balance. Osteoclasts are distributed on the surface of bones. Osteoclasts secrete substances such as hydrochloric acid to break down bone tissue. Throughout the life cycle, bones are constantly formed and destroyed, maintaining a dynamic balance. If the balance is broken and osteoclasts are too active, it will lead to osteoporosis and an increase in osteoclasts. In this case, it is necessary to supplement calcium and vitamin D3 in time to promote calcium absorption.