What is the disease that causes right chest tightness, hiccups and acid reflux?

In our lives, heartburn is still very common, just like there is some sulfuric acid in the stomach, which makes one feel hot. In fact, the so-called acid water is gastric acid. Its secretion is mainly to promote the digestion of food, just like a catalyst in chemical experiments. Well, some friends always burp, and every time they burp, there will be acid water. What disease causes this?

1. Medical treatment

The goals of medical treatment are to relieve reflux and reduce the irritation and erosion of gastric secretions. Generally, asymptomatic sliding hernias do not require treatment. Medical treatment can be performed for patients with mild symptoms of reflux esophagitis or due to age, comorbidities, or unwillingness to undergo surgery. For obese patients, weight loss can reduce intra-abdominal pressure and reflux. Avoid lifting heavy objects, bending over, etc., and do not wear tight clothes. Raise the head of the bed 15 cm when sleeping, do not eat 6 hours before going to bed, avoid smoking and drinking, all of which can reduce the onset of esophageal reflux.

In terms of drug treatment, antacids can be used to neutralize gastric acid and reduce the activity of pepsin. Gastrokinetic drugs can be used to prolong gastric emptying. The combined use of acid-suppressing drugs and prokinetic drugs can improve the therapeutic effect for some patients.

2. Promote the emptying of the esophagus and stomach

(1) Dopamine antagonists

This type of drug can promote the emptying of the esophagus and stomach and increase the tension of the LES. These drugs include metoclopramide (Metoclopramide) and domperidone (Motilium), which are taken at bedtime and before meals. The former can cause extrapyramidal neurological symptoms if taken in excessive doses or for long periods of time, so it should be used with caution in elderly patients; the latter can also cause hyperprolactinemia and produce adverse reactions such as breast hyperplasia, lactation and amenorrhea if taken for long periods of time.

(2) Cisapride can release acetylcholine through the postganglionic nerves of the intestinal plexus, thereby promoting the peristalsis and emptying of the esophagus and stomach, thereby alleviating gastroesophageal reflux.

(3) The cholinergic drug uracil can increase the tension of the LES, promote esophageal contraction, and accelerate the emptying of acidic food in the esophagus to improve symptoms. This medicine can stimulate gastric acid secretion, so long-term use should be cautious.

3. Reduces stomach acid

(1) Antacids

It can neutralize gastric acid, thereby reducing the activity of pepsin and reducing the damage of acidic gastric contents to the esophageal mucosa. Alkaline drugs themselves also have the effect of increasing LES tension. Aluminium hydroxide gel and magnesium oxide. Alginic acid foam contains alginic acid, sodium alginate and antacids, which can float on the surface of gastric contents and prevent reflux of gastric contents.

(2) Histamine H2 receptor antagonists

Cimetidine, furosemide and famotidine can all be used. This type of drug can strongly inhibit gastric acid secretion and improve gastroesophageal acid reflux. If the above symptoms cannot be improved, the dosage can be increased to 2 to 3 times.

(3) Proton pump inhibitors

This type of drug can block the H+-K+-ATPase of parietal cells. Drugs such as omeprazole and lansoprazole have been widely used in clinical practice.