Pseudoephedrine hydrochloride

Maybe many people don’t know much about pseudoephedrine hydrochloride. Because it is relatively rare in our lives, but their therapeutic effects are relatively good. When we treat some allergic rhinitis or rhinitis symptoms, pseudoephedrine hydrochloride is a relatively key drug, so it is necessary for everyone to understand it, which can also increase our medical knowledge.

This article introduces the functions, indications and examination methods of pseudoephedrine hydrochloride. These are the main ways for us to understand the composition of pseudoephedrine hydrochloride. Let’s come in and read the methods and main functions mentioned in the article.

5 Functions and indications: Relieve symptoms of nasal congestion caused by colds, allergic rhinitis, rhinitis and sinusitis, and control bronchial asthma.

Characteristics

This product is white crystalline powder; odorless, bitter taste.

This product is very soluble in water, easily soluble in ethanol, and slightly soluble in chloroform.

Melting pointThe melting point of this product (Appendix Ⅵ C) is 183 ~ 186 ℃.

Specific rotation: Take the product, weigh it accurately, dissolve it in water and quantitatively dilute it to make a solution containing about 50 mg per 1 ml. Determine it according to the method (Appendix Ⅵ E). The specific rotation is +61.0° to +62.5°.

Identification

(1) Take this product and add water to make a solution containing 0.5 mg per 1 ml. Determine by spectrophotometry. Maximum absorption is found at wavelengths of 251 nm, 257 nm and 263 nm.

(2) The infrared absorption spectrum of this product should be consistent with the reference spectrum (Figure 642 of Spectral Collection).

(3) The aqueous solution of this product shows the identification reaction of chloride.

To check the acidity and alkalinity, take 0.2g of this product, add 10ml of water to dissolve it, and add 1 drop of methyl red indicator solution. If it appears light red, add 0.10ml of sodium hydroxide titration solution (0.02mol/L), and it should turn yellow; if it appears yellow, add 0.10ml of hydrochloric acid titration solution (0.02mol/L), and it should turn red.

Clarity and color of the solution Take 1g of this product and dissolve it in 20ml of water. The solution should be clear, almost without opalescence, and colorless. If it is turbid, it should not be thicker than the No. 1 turbidity standard solution (Appendix Ⅸ B).

Loss on drying: Take this product and dry it at 105°C to constant weight. The loss in weight shall not exceed 0.5% (Appendix VIII L).

The residue on ignition shall not exceed 0.1% (Appendix VIII N).

Take 1.0g of this product, add 23ml of water to dissolve it, add 2ml of acetate buffer (pH3.5), and check according to law. The heavy metal content shall not exceed 20 parts per million.

Content determination

Take about 0.3g of this product and weigh it accurately. Add 10 ml of glacial acetic acid, dissolve it with slight heat, then add 5 ml of mercuric acetate test solution and 1 drop of crystal violet indicator, titrate with perchloric acid titrant (0.1 mol/L) until the solution turns blue-green, and correct the titration result with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) is equivalent to 20.17 mg of C10H15NO.HCl.

In fact, in life, if we want to use a medicine correctly, we need to first understand its main ingredients and therapeutic effects, so that we can better eliminate the side effects of the medicine. At the same time, we hope that everyone will read more medical knowledge, communicate more with friends, and exercise more. Only in this way can we fundamentally avoid the impact of the disease. I hope everyone can stick to it.