Nephrogenic diabetes insipidus

In fact, in many cases, our bodies have already encountered a lot of unnecessary troubles, but with the improvement of people's quality of life, the things people pursue are also constantly improving. That is why people will pay some attention to everything about themselves, and this disease called nephrogenic diabetes insipidus is one of them. However, I also hope that everyone can understand more about this disease. This is also good for us.

This type of nephrogenic diabetes insipidus has actually been well known in society for a long time. Because it is relatively common, there is no need to worry too much. Below is some information about this disease.

Delayed development of the neuroendocrine system in the brain

(1) Detrusor instability or low-compliance bladder (high sensitivity to urine storage), reduced bladder functional capacity, and the actual amount of urine that can be stored is smaller than normal. Patients often have frequent urination during the day or before bedtime, urgency, and even urinary incontinence.

(2) The bladder filling and contraction sensing function is incomplete, and the bladder filling and contraction fail to wake the patient from sleep.

(3) Incomplete urethral closure function, that is, unstable urethra. It also manifests as frequent urination, urgency, urinary incontinence, etc.

(4) Insufficient secretion of antidiuretic hormone (ADH) from the pituitary gland results in increased urine production at night, exceeding the capacity of the bladder.

Sleep Factors

In the early days, it was generally believed that enuresis was caused by deep sleep and high awakening threshold. In fact, enuresis has nothing to do with the depth of sleep, and enuresis does not occur during deep sleep.

A large number of nocturnal continuous EEG studies have shown that:

(1) Arousal dysfunction is an important cause of enuresis. Incomplete bladder filling and contraction perception function and excessive fatigue leading to deep sleep can all lead to arousal dysfunction.

(2) Poor urination control function is more significant after falling asleep, indicating that delayed development of urination control function plays an important role in the occurrence of enuresis.

(3) The sleep cycle of patients with enuresis is in a disordered state, which is more obvious in patients who are often woken up to urinate at night.

Mental, psychological and behavioral abnormalities

Enuresis can lead to mental, psychological and behavioral abnormalities in patients, which in turn become one of the reasons for persistent and intractable enuresis in patients, especially older children and adults.

Fear of enuresis and the hope of preventing enuresis by urinating multiple times are common psychological factors of this type of patients. Influenced by this psychology, patients still remind themselves to urinate during sleep, and the frontal lobe detrusor center in the brain is highly excited, which increases the sensitivity and contractility of the bladder, and a small bladder capacity can produce the urge to urinate. If the brain produces a dream scene that allows urination, the detrusor muscle will be vaguely strengthened in the awareness of urination, and at the same time, the urethral sphincter will relax and enuresis will occur, which in turn causes a decrease in the functional capacity of the bladder.

In addition, the secretion of ADH and psychological changes are both controlled by the hypothalamus of the brain, so the two are closely related.

other:

Phimosis, prepuce, urethral stricture and other urinary system diseases; long-term constipation or diarrhea, anal fissure, irritable bowel syndrome and other gastrointestinal diseases; pituitary or nephrogenic diabetes insipidus; diabetes; food allergies; enterobiasis, ascariasis and other intestinal parasites; heart, liver, kidney, lung and other body diseases can all be the cause of enuresis, accounting for about 10% of enuresis patients.

Through the above understanding and introduction, I believe everyone has a certain understanding of this type of nephrogenic diabetes insipidus. At the same time, I hope that everyone can be helped by the above knowledge. At the same time, I also hope that everyone can make good use of the above information, because it is more useful. At the same time, everyone should eat more green foods in daily life.