Side effects of metronidazole

Metronidazole is mainly used to treat the intestines and some digestive tracts. It can also treat some pediatric trichomoniasis and some skin diseases. In daily life, it is mainly used for vaginal infections and treatments, so it is also used for treatments in daily life. Its usage and dosage are generally 0.4 to 0.6 grams three times a day. The dosage in life is also different according to different opinions on different diseases.

Therefore, some effects or adverse reactions will occur in daily life, the main ones are adverse reactions of the digestive tract including nausea, vomiting, loss of appetite and pain, and those of the nervous system are mainly headaches, abnormal sensations and some limb numbness.

Adverse reactions occur in 15% to 30% of cases, with gastrointestinal reactions being the most common, including nausea, vomiting, loss of appetite, and abdominal cramps, which generally do not affect treatment; neurological symptoms include headache, dizziness, and occasionally paresthesia, limb numbness, ataxia, multiple neuritis, etc. Large doses can cause convulsions. In a few cases, urticaria, hot flashes, itching, cystitis, dysuria, metallic taste in the mouth and leukocytopenia may occur, which are all reversible and recover on their own after stopping the drug.

This product can enhance the effect of anticoagulant drugs such as warfarin. Combination with oxytetracycline may interfere with the effect of metronidazole in eliminating Trichomonas vaginalis.

Pharmacological action: This product is a nitroimidazole derivative that can inhibit the redox reaction of amoeba and cause the nitrogen chain of the protozoa to break. In vitro tests have shown that when the drug concentration is 1-2 mg/L, Entamoeba histolytica will undergo morphological changes in 6-20 hours and will be completely killed within 24 hours. When the concentration is 0.2 mg/L, Entamoeba histolytica can be killed within 72 hours. This product has a powerful effect of killing trichomonas, but its mechanism is unknown. Metronidazole has a killing effect on anaerobic microorganisms. The metabolites generated when it is reduced in the human body also have anti-anaerobic effects, inhibiting the synthesis of bacterial deoxyribonucleic acid, thereby interfering with bacterial growth and reproduction, and ultimately causing bacterial death. It is carcinogenic to some animals.

The above are the side effects of metronidazole. Large doses can cause convulsions, urticaria and papules. Adverse reactions of the digestive tract include nausea, vomiting, loss of appetite and pain. The main symptoms of the nervous system are headaches, paresthesias, numbness of the limbs, and difficulty urinating. Therefore, in daily life, you still need to take metronidazole according to the prescription issued by the doctor. .