What is the cause of nephritis caused by Henoch-Schonlein purpura?

Purpura is an allergic vasculitis that invades the skin and capillaries. More and more people are suffering from allergic purpura. The early symptoms are not obvious, so many people do not take it seriously. It is easy to cause nephritis due to severe purpura. So what are the causes of nephritis caused by Henoch-Schonlein purpura?

The reason why Henoch-Schonlein purpura causes nephritis is that the antigens produced by the pathogenic factors combine with antibodies in the body to form immune complexes (ICs). The immune complexes are most likely to deposit in the glomeruli, activating complement, leading to the migration and chemotaxis of neutrophils and the release of a series of inflammatory mediators, causing vascular inflammatory reactions, increased vascular fragility and permeability, and leading to the occurrence of Henoch-Schonlein purpura nephritis. This is the reason why Henoch-Schonlein purpura causes nephritis.

The reasons why immune complexes (ICs) are most likely to be deposited in the glomeruli are:

① The glomerular basement membrane is a filter plate, and medium-sized ICs are easily retained and embedded in the glomerular basement membrane;

② Glomerular endothelial cells have C3b receptors, and IC containing complement easily binds to them and deposits;

③ The kidneys have large blood flow, the glomerular microvessels have many branches, the blood vessels are thin and tortuous, and the blood flow is slow, which is conducive to IC deposition.

The above content is the reason why Henoch-Schonlein purpura causes nephritis introduced by experts. Everyone should pay attention to it. I hope it will be helpful to you. Once you suffer from Henoch-Schonlein purpura and nephritis, you should seek treatment as soon as possible.