Is proteinuria in nephrotic syndrome serious? what to do?

Nephrotic syndrome is a common disease in life. The occurrence of proteinuria is mainly due to damage to the filtration membrane in the kidney, which increases the permeability and causes proteinuria leakage. So what is the specific cause of proteinuria in nephrotic syndrome? Is it serious? What are the hazards?

Causes of proteinuria

Generally, healthy people have only a small amount or no protein in their urine, but due to various factors, the body's regulatory mechanism is disrupted. When encountering various factors such as colds and infections, immune allergic reactions occur, and anti-inflammatory antibodies combine to produce immune complexes, leading to ischemia and hypoxia of local kidney tissues. Endothelial cells are damaged, attracting inflammatory cells to infiltrate and produce inflammatory reactions, and kidney tissue fibrosis is initiated. At the same time, pathological changes occur in the glomeruli and the glomerular filtration membrane is damaged. As a result, large molecular proteins and red blood cells that cannot leak out of the body leak out of the glomerulus, exceeding the renal tubular reabsorption function, so proteinuria appears in clinical tests.

The dangers of proteinuria in nephrotic syndrome

Clinically, proteinuria 2+ is very harmful. Patients with kidney disease excrete a large amount of proteinuria. Hypoproteinemia often causes a decrease in colloid osmotic pressure, making edema stubborn and difficult to eliminate, and the body's resistance also decreases accordingly. The degree of urinary protein is highly correlated with the worsening of kidney disease.

The occurrence of proteinuria 2+ is not only a massive loss of nutrient protein, but also causes damage to the glomeruli, renal tubules, etc., thereby causing renal fibrosis. Studies have confirmed that the occurrence of proteinuria 2+ is the first independent risk factor for uremia. The greatest harm of proteinuria 2+ is that it poisons the kidneys and causes uremia.

At the same time, the hazards of proteinuria 2+ are also reflected in the mesangial toxicity of proteinuria 2+, the toxic effect of proteinuria 2+ on proximal tubular cells, the biological changes of tubular cells caused by proteinuria 2+, and the aggravation of tubular interstitial hypoxia caused by proteinuria 2+. These aspects need to be taken seriously and actively treated.

I hope the above content can be helpful to you and wish you a speedy recovery.