What causes cerebral thrombosis? What are the factors that cause cerebral thrombosis?

Cerebral thrombosis is the abbreviation of cerebral thrombosis. It is a common and frequent disease that occurs on the basis of cerebral arterial intimal lesions, increased blood viscosity, slow blood flow, arrhythmia and other factors, causing narrowing or complete obstruction of the cerebral artery lumen, speech impairment and other localized neurological dysfunctions. So what causes cerebral thrombosis?

1. Vascular disease

The most important and common vascular disease is atherosclerosis, followed by cerebral arteriosclerosis associated with hypertension. Others include vascular developmental abnormalities, such as congenital aneurysms and cerebrovascular malformations;

Vasculitis, such as endarteritis caused by infectious rheumatic fever, tuberculosis, leptospirosis, syphilis, etc.; some non-infectious vasculitis, such as thromboangiitis obliterans, polyarteritis nodosa, arterial wall trauma such as injury, surgery, catheterization, puncture, etc.; rare dissecting aneurysms of the aorta and carotid artery, etc.

2. Changes in blood composition

The inner membrane of the vascular lesions is rough, making it easy for platelets in the blood to adhere, accumulate, and release more chemical substances such as serotonin. The increase in the content of lipoprotein, cholesterol and fibrinogen in the blood components can increase blood viscosity and slow down blood flow. In addition, blood diseases such as leukemia, polycythemia and various factors that increase blood coagulation make cerebral thrombosis more likely to occur.

3. Hemodynamic Changes

The regulation of cerebral blood flow is affected by many factors. Changes in blood pressure are an important factor affecting local blood volume in the brain. When the mean arterial pressure is lower than 9.5 kPa (71 mmHg) and higher than 24 kPa (180 mmHg), the blood supply to local brain tissue may be impaired due to lesions in the blood vessels themselves, stenosis of the lumen, and failure of the automatic regulation function.

In addition, some people have conducted network regression analysis on patients with cerebral thrombosis by matching them with patients with other diseases and collecting more than 30 components such as age, gender, ethnicity, marital status, smoking, drinking, diet, mental stimulation, physical exercise, weight, blood pressure, blood sugar, electrocardiogram, and serum cholesterol.

It was found that a history of hypertension, abnormal electrocardiogram, heart disease, diabetes, hyperlipidemia, a family history of hypertension, overweight and a preference for fatty meat were associated with the incidence of cerebral thrombosis, in the order of history of hypertension, systolic blood pressure, body mass index and reduced high-density lipoprotein, which were the main factors affecting cerebral thrombosis. Physical exercise can reduce the occurrence of cerebral thrombosis.