What are the fatal symptoms of Parkinson's?

Parkinson's disease is actually a relatively common disease. Most of the people we see with persistent hand tremors in life suffer from Parkinson's disease, which is also a relatively obvious symptom of this disease. Patients with Parkinson's disease actually have other symptoms, such as bradykinesia, muscle rigidity, etc. If the disease is not controlled in time, it will also affect the patient's normal life.

Clinical manifestations of Parkinson's disease

The onset is insidious and the progression is slow. The first symptom is usually a tremor or clumsiness on one side, which then spreads to the other side. The main clinical manifestations are resting tremor, bradykinesia, muscle rigidity and posture and gait disorders. In recent years, people have increasingly noticed that non-motor symptoms such as depression, constipation and sleep disorders are also common complaints of Parkinson's disease patients, and their impact on patients' quality of life is even greater than that of motor symptoms.

Static tremor: About 70% of patients have tremor as the first symptom, which usually starts from the distal end of one upper limb. It appears or is obvious when the patient is at rest, decreases or stops during voluntary movement, worsens during mental stress, and disappears after falling asleep. Resting tremor of the hands that worsens during walking. The typical manifestation is a "pill-rolling" tremor with a frequency of 4 to 6 Hz. Some patients may have postural tremor. The patient's typical complaint is: "One of my hands often shakes. The more I sit still, the more it shakes. It stops shaking when I'm working or picking up things. It also shakes violently when I meet strangers or get excited. It stops shaking when I fall asleep."

When the examiner moves the patient's limbs, neck or trunk, he or she can feel obvious resistance. This increase in resistance is uniform and consistent in all directions, similar to the feeling of bending a soft lead pipe, so it is called "lead-pipe rigidity." When the patient has limb tremors, intermittent pauses may occur in uniform resistance, like turning gears, so it is called "cogwheel rigidity". The patient's typical complaint is "My limbs are stiff and stiff." In the early stages of the disease, muscle stiffness is sometimes difficult to detect. At this time, the patient can actively move one limb, and the muscle tone of the affected limb will increase with passive movement.

Bradykinesia Bradykinesia refers to slowing of movements, difficulty initiating movements, and loss of active movement. Patients may experience a reduced range of motion, especially with repetitive movements. Bradykinesia can manifest in many ways, depending on the area affected. Facial expressions and movements are reduced, and blinking is called a masked face. The speaking voice is monotonous and low, and the pronunciation is not clear. Writing can become slower and smaller, which is called "micrographia". Washing, dressing and other fine motor skills may become clumsy and inflexible. The walking speed becomes slower and the patient often shuffles, and the arm swing range gradually decreases or even disappears. The step size becomes smaller. Drooling occurs because the saliva cannot be swallowed actively. Turning over may be difficult at night. In the early stages of the disease, patients often mistake bradykinesia for weakness, and are often misdiagnosed as having cerebrovascular disease or cervical spondylosis due to soreness, swelling and weakness in one limb. Therefore, when patients gradually develop weakness in one limb and are accompanied by increased muscle tone, they should be alert to the possibility of Parkinson's disease. Typical complaints of early patients are: "I recently found that my right hand (or left hand) is not as good as before, my handwriting is not as beautiful as before, and when I beat eggs, I feel that my right hand is not obedient and is not as flexible as the other hand. When I walk, I feel that my right leg (or left leg) is heavy and seems to be dragging."