Causes of elevated cholesterase

Causes of elevated cholesterase

Cholesterol lipase is a glycoprotein that can participate in many tasks. When the level of cholesterol lipase is high, it may be that the patient's liver function is abnormal, and the harm to the body is relatively large at this time. It must be taken seriously. This is also a better physical examination method. The more common ones are acute viral hepatitis, chronic hepatitis, or subacute severe hepatitis, etc., which can easily lead to hepatic coma in patients.

Causes of elevated cholesterase

Since there are many reasons for high cholesterase, we cannot generalize the question of what to do if cholesterase is high. We need to decide based on the patient's condition. This requires patients to undergo further comprehensive examinations to find out the real cause of the high cholesterase level and treat it with symptomatic medication. Finally, the doctor reminded that for patients with liver disease, whether it is liver function or other examination items that are abnormal, they should pay attention to it to avoid worsening of the disease!

Significance of the examination: There are two types of cholesterase in the human body. One is acetylcholine esterase, also known as "true cholesterase" or "specific cholesterase", which mainly acts on acetylcholine and exists in red blood cells and gray matter of the central nervous system; the other is serum cholesterase, which has poor specificity. In addition to acetylcholine, it can also act on other cholesteryls, so it is also called "pseudocholesterase" or "non-specific cholesterase". This enzyme is mainly produced by the liver. The normal human serum choline esterase content measured by colorimetry is 130~310 units/L. Since serum cholinesterase is synthesized by the liver, decreased activity of this enzyme often reflects liver damage.

1. Acute viral hepatitis: The decrease in serum choline esterase is related to the severity of the disease, but not necessarily parallel to the degree of jaundice. If the activity continues to decrease, it often indicates a poor prognosis. 2. Chronic hepatitis: The activity of this enzyme does not change much in patients with chronic persistent hepatitis, and the activity of this enzyme in patients with chronic active hepatitis is similar to that in patients with acute hepatitis. 3. Liver cirrhosis: If the liver is in the compensatory stage, serum cholinesterase is usually normal. If the liver is in the decompensated stage, the activity of this enzyme decreases significantly. 4. In patients with subacute severe hepatitis, especially those with hepatic coma, serum cholinesterase levels are significantly reduced[3], and the reduction is often persistent. 5. In patients with extrahepatic biliary obstructive jaundice, serum cholinesterase is normal. If accompanied by biliary cirrhosis, the activity of this enzyme will decrease.

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