Is hyperprolactinemia a serious disease?

Many people in life are not clear about what hyperprolactinemia is. It is a common physiological balance disease, which can cause many physiological problems in patients. It may even need to be maintained by various drugs in clinical practice to be reduced. Only by reducing and adjusting the balance can the body be healthy. Therefore, in normal times, it is more important to master the treatment methods of traditional Chinese medicine, so that recovery will be faster.

Treatment and prevention:

Treat primary diseases (pituitary tumors, hypothyroidism, and Cushing's syndrome); try to avoid adverse mental stimulation; reduce or avoid the use of drugs that increase prolactin.

TCM treatment of hyperprolactinemia:

Traditional Chinese medicine believes that the cause and pathogenesis of this disease is relatively complex, but in principle it can be divided into two categories: deficiency and excess. Deficiency refers to liver and kidney deficiency, insufficient essence and blood, and an empty blood sea. When there is no blood to flow, amenorrhea will occur; when qi and blood are weak and kidney qi is not solid, milk will overflow. It is actually caused by liver depression and qi stagnation, blood stasis and phlegm obstruction, which block the meridians and force menstrual blood to flow downward; or it is caused by heat accumulation in the liver meridians and abnormal blood secretion, which forces milk to overflow. Due to insufficient endowment, the kidney qi is not strong, the essence is not sufficient, the liver blood is deficient, the Chong and Ren meridians are not nourished, and cannot be transformed into menstrual blood; or due to sexual overwork or long-term illness, the kidney essence is depleted, the liver blood is also deficient, the essence and blood are scarce, the source is cut off, the Chong and Ren meridians are damaged, and there is no blood to flow out of the uterus, resulting in amenorrhea. As stated in "Medical Biography": "Menstruation is entirely dependent on kidney water. Once the kidney water is exhausted, the menstrual water will dry up day by day." Or the kidney yang is deficient, the yang qi cannot reach the body, the yang deficiency causes cold, and the deficiency cold causes blood stagnation; or the kidney yang deficiency cannot warm the spleen and strengthen the body, and the absorption is powerless, which can be seen as the milk is digested and discharged. If the spleen and stomach are weak, or if one eats too much, is overworked, takes medicine improperly, or is overly worried, the heart and spleen will be damaged, and the blood will be insufficient; or if one is seriously ill for a long time, has an abortion or miscarriage, etc., which results in blood loss, or if one breastfeeds for too long and damages Qi and consumes blood, the Chong and Ren meridians will be deficient, the sea of ​​blood will be empty, and no blood can be discharged, resulting in amenorrhea. As it is said in "Lanshi Mi Zang", "A woman's spleen may be in need for a long time, or her body may be weak and her qi and blood may be weakened, which may lead to the cessation of menstruation." If the seven emotions cause internal damage, the liver qi may be stagnant, qi may stagnate and blood may stagnate, the Chong and Ren meridians may be blocked, the uterine vessels may be congested, and menstruation may be blocked, thus causing amenorrhea; or if anger and depression damage the liver, the liver fire may be hyperactive, and the discharge of qi may be excessive, forcing milk to overflow. "The Heart of Pregnancy and Childbirth" says: "The anger of the liver meridian rushes upward, and the breasts swell and overflow." In addition, obese people have a lot of phlegm and dampness, which block the meridians; or the spleen yang is dysfunctional, and the dampness gathers into phlegm, and the fat, phlegm and dampness block the Chong and Ren meridians, causing the uterine vessels to be blocked and menstruation to not flow. "Essentials of Gynecology" said: "Fat and white people who have amenorrhea and menstruation must be due to the obstruction of damp phlegm and lipid membrane." In summary, the occurrence of this disease involves deficiency of the liver, spleen, and kidney, resulting in deficiency of essence, qi, and blood, or due to obstruction of qi, blood, and phlegm.

Western medicine treatment of hyperprolactinemia

Drug treatment: Bromocriptine is a semi-synthetic ergoline derivative and a dopamine receptor agonist. It can promote the synthesis and secretion of PRL-IH and inhibit the synthesis and release of PRL through the receptor mechanism. It also directly acts on pituitary tumors and PRL cells to curb tumor growth and inhibit the secretion of PRL, GH, TSH and ACTH.

Bromocriptine therapy is suitable for all types of HPRL and is also the first choice for pituitary adenomas (micro/macroadenomas), especially for young infertile women who hope to have children. The dosage is 2.5-7.5 mg/d, orally. Other anti-prolactin drugs include: Levodopa, octahydrobenzoquinoline (CV205-502), vitamin B6, etc. See the Anti-prolactin section in the Endocrine Therapy chapter for details.

Ovulation induction therapy

It is suitable for patients with HPRL, anovulatory infertility, and those who cannot successfully ovulate and become pregnant after simple bromocriptine treatment. That is, a comprehensive therapy with bromocriptine as the main drug and other ovulation-inducing drugs in combination: ① bromocriptine-CC-hCG; ② bromocriptine-hMG-hCG; ③ GnRH. Pulse therapy - bromocriptine, etc. Combined therapy can save antiprolactin, shorten the treatment cycle and improve the ovulation rate and pregnancy rate.