Premature ovarian failure but natural pregnancy

The occurrence of premature ovarian failure only means that the ovarian function has declined, but it does not necessarily mean that women cannot produce eggs. So premature ovarian failure may occur at this time, but you may get pregnant naturally. Don’t worry too much about being pregnant at this time. If you strengthen your daily good care and do a good job of protecting the fetus, it will not have a big impact on the fetus, and it will not cause too much harm to the health of the pregnant woman.

Premature ovarian failure will affect pregnancy. 1. The normal function of the ovaries is suppressed, resulting in ovarian dysfunction, which can be manifested as infrequent menstruation, reduced menstrual volume, anovulation and luteal insufficiency, and finally amenorrhea. This can also lead to infertility.

2. Affects ovulation function. Some cases are accompanied by increased testosterone (T) in the blood. Increased testosterone can neutralize estradiol in the blood, reduce estradiol, and affect the development and maturation of follicles and normal ovulation. At the same time, excessive testosterone can hinder follicles and ovulation, causing them to atrophy and close. Without normal ovulation, infertility will occur.

3. Premature ovarian failure is caused by excessive levels of follicular estrogen (FSH) and luteinizing hormone (LH) in the blood, which feedback inhibit the ovaries from producing estradiol and progesterone. This condition is called premature ovarian failure, which first causes a decrease in menstrual volume, a delay of 1-2 months in the menstrual cycle, and finally amenorrhea. Due to irregular menstruation or amenorrhea, infertility will naturally occur.

4. Premature ovarian failure may be accompanied by oophoritis, and ovarian inflammation is included in the scope of female pelvic inflammatory disease. There are specific inflammation and nonspecific inflammation. Due to bacterial infection, the ovaries may become inflamed, which may lead to serious sequelae such as ovarian adhesions, ovarian and fallopian tube encapsulation, ovarian and fallopian tube abscesses, fallopian tube obstruction, and ovarian ovulation disorders, resulting in infertility.

Treatment of premature ovarian failure

1. Hormone therapy: It can improve symptoms such as facial flushing, menstrual disorders, vaginal dryness, etc. caused by decreased estrogen levels, but this treatment method lasts for a long time and must be used under the guidance of a professional gynecologist to continuously adjust the usage, dosage and route of the drug. In addition, regular physical examinations are required, preferably once a year.

Cyclic supplementation of estrogen and progesterone can avoid epithelial atrophy and calcium loss in the reproductive organs, and can protect the cardiovascular system and prevent changes in lipid metabolism. Oral estrogen can be started at any time, but it should be injected intramuscularly daily starting a few days after taking estrogen, and continuous injections are required.

2. Immunotherapy: Immunotherapy can be performed for those who are found to have antibody factors. Immunization by injection has become a more reliable treatment method.

3. Surgical treatment:

① For POF caused by ovarian vascular factors leading to ovarian nutrition deficiency, early diagnosis and early treatment should be carried out, and vascular bypass surgery should be performed as soon as possible before the ovarian function is completely lost, such as anastomosis of the ovarian artery with the inferior mesenteric artery or renal artery, to restore the ovarian blood supply and restore the vitality of the ovary;

② For those who are in the late stage of POF or have ovarian deficiency due to various reasons, ovarian transplantation has become a very successful treatment method.