Some side effects and effects of Propane

Propanedine can be adjusted in normal times. A few people may have gastrointestinal diseases. You need to consult a doctor about which specific adjustment to make, because there is no definitive conclusion on the diseases this drug can treat. It mainly plays an auxiliary role in many more complicated diseases. A few people may experience urinary retention, blurred vision, dizziness and headache after using it. These symptoms can be relieved after stopping the drug.

Mechanism of action: This product has a strong atropine-like peripheral anticholinergic and antimuscarinic effect, and also has a weak ganglion blocking effect. It can bind to the cholinergic receptors on parietal cells and G cells, but does not produce the effect of stimulating the receptors. Instead, it only competitively blocks the binding of acetylcholine to the receptors, thereby reducing gastric acid secretion. The inhibitory effect on basal acid secretion is most obvious when the stomach is fasting, and it is believed that taking it before bedtime can reduce gastric acid secretion at night in patients with duodenal ulcers, so patients should take it before or 1 hour after meals. Its characteristic is that it is selective for gastrointestinal smooth muscle, so its inhibitory effect on gastrointestinal smooth muscle is stronger and more lasting. It also has varying degrees of inhibitory effect on sweat and saliva secretion. This product does not easily pass through the blood-brain barrier, so it rarely has central effects.

Pharmacokinetics : Oral gastrointestinal absorption is incomplete, 50% of the drug is absorbed after hydrolysis in the gastrointestinal tract, and only 10% is absorbed as active substances. Parenteral administration has a higher plasma concentration than the same oral dose. Metabolized in the liver. About 70% is excreted in the urine as metabolites and 3% as unchanged drug, with a duration of action of about 6 hours. The plasma elimination t1/2 is approximately 1.6h. Adverse reactions: The main adverse reactions include dry mouth, blurred vision, urinary retention, constipation, headache, palpitations, etc., which can disappear after reducing the dosage or stopping the drug. Avoid using before surgery and in patients with glaucoma; use with caution in patients with heart disease.

Note: This product is an anticholinergic drug that can relax gastrointestinal smooth muscle and prolong gastric emptying time; while metoclopramide can increase gastric motility and improve the passage rate of gastric contents; when the two are used together, their pharmacological effects are antagonistic and the efficacy is affected. This product may also affect the absorption of some drugs. For example, erythromycin may be decomposed and reduced in efficacy due to the influence of gastric acid after staying in the stomach for too long; the absorption of acetaminophen may be delayed, thereby reducing the peak plasma concentration; this product can increase the plasma concentration of digoxin by 33%-50%, and increase its AUC by 24% compared to when it is used alone; the absorption of furantoin may also be increased as a result. Do not mix with alkaline drugs.

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