Anti-double-stranded DNA antibody negative

Anti-double-stranded DNA antibody is a type of anti-DNA antibody. This antibody is of relatively important significance in clinical examinations. It can perform good examinations of kidney damage and is a sign of kidney damage examination. In addition, it is also of certain value in judging the prognosis. For example, patients with systemic lupus erythematosus, chronic active hepatitis, connective tissue diseases, etc., all undergo this examination.

Abnormal results of clinical significance : Anti-dsDNA autoantibodies are the most important autoantibodies in SLE, with a detection rate of 40%-70%. The presence of high titer anti-dsDNA is an important basis for the diagnosis of SLE and is also a sign of disease activity, especially kidney damage. In addition to being used for the diagnosis of SLE, it can also be used to monitor the clinical course and treatment effects, and has certain value in determining prognosis. However, some people have reported finding low-titer anti-dsDNA positivity or increased levels in patients with liver disease, juvenile rheumatoid arthritis, and even in normal people: this may be systemic lupus erythematosus, and can also be seen in other connective tissue diseases, chronic active hepatitis, etc. People who need to be checked: those who suffer from the above diseases