Pingyangmycin for the treatment of hemangioma

Pingyangmycin is widely used in today's medicine. It was originally cultured from actinomycetes in Zhejiang Province, my country. It is a white loose solid antibiotic that can be used for anti-tumor. It can not only treat malignant diseases such as esophageal cancer, breast cancer, cervical cancer, nasal polyps, but also has significant effects in the treatment of hemangiomas. Friends in need can learn more about the relevant knowledge.

1. Pingyangmycin

Pingyangmycin is an antitumor antibiotic isolated from the culture fluid of actinomycetes (Streptomyces pingyangensis n.sp) in the soil of Pingyang County, Zhejiang Province, my country. Research has shown that its ingredients are similar to those of foreign Bleomycin. Comparing the two, bleomycin is a multi-component compound drug, the main ingredient of which is A2, while bleomycin is a single component A5. Practice has shown that this product has a good therapeutic effect on squamous cell carcinoma, while its pulmonary toxicity is relatively low. This product has a similar effect to bleomycin, mainly inhibiting the incorporation of thymidine into DNA and binding to DNA to destroy it. In addition, it can also break the single-stranded DNA and release some free nucleobases, which may destroy the DNA template and prevent DNA replication.

2. Symptoms

Squamous cell carcinoma of the head and neck

Skin cancer, esophageal cancer, breast cancer, cervical cancer, penis cancer, vulvar cancer, liver cancer

Malignant lymphosarcoma, necrotizing granuloma

Hemangioma, lymphangioma, nasal polyps, pterygium

Sexually transmitted diseases such as genital warts, psoriasis, vitiligo, flat warts, etc.

3. The principle of Pingyangmycin in treating hemangioma

Hemangioma is an angiogenic disease. Uncontrolled angiogenesis is the main cause of its proliferation. It is characterized by excessive proliferation of the vascular endothelium, with obvious proliferative and degenerative phases. Studies have found that caspase-3 is involved in the pathological process of hemangioma transitioning from the proliferative phase to the regressive phase. The activation of caspase-3 induces cell apoptosis, which may be one of the main factors for the spontaneous regression of hemangioma.

Vascular endothelial growth factor (VEGF) can induce and regulate the proliferation of endothelial cells and plays a key role in the development of hemangiomas. Therefore, inhibiting and blocking endothelial cell proliferation, inducing endothelial cell apoptosis, and accelerating tumor regression will be helpful in the treatment of hemangioma. Pingyangmycin is a bleomycin produced by Streptomyces pingyangensis. It is a new antitumor antibiotic that is increasingly gaining attention in the local treatment of pediatric hemangiomas because of its low toxicity and little effect on the body's immune function and hematopoietic system, making it more suitable for use in children. Its mechanism of treating hemangioma is to rapidly inhibit the proliferation of vascular endothelial cells and destroy the sinusoidal endothelium, thereby promoting the regression of hemangioma. Capillary hemangiomas and mixed hemangiomas still have the characteristics of immature embryonic vascular endothelium. Injection of bleomycin into the tumor can quickly inhibit endothelial cell proliferation and promote the regression of hemangiomas.