Adverse reactions of metoprolol tartrate controlled-release tablets

Metoprolol tartrate controlled-release tablets are a common drug used to treat hypertension and angina pectoris. We know that hypertension and angina pectoris are relatively common cardiovascular diseases. When some obvious symptoms appear, this drug can be used for treatment under the guidance of a doctor. When using the drug, you must understand some side effects and adverse reactions. During the use of the drug, it may cause headaches, insomnia, hallucinations, depression and other symptoms.

Adverse Reactions

1. Cardiovascular system: slow heart rate, conduction block, low blood pressure, worsening heart failure, cold limbs or untouchable pulse due to peripheral vasospasm, Raynaud's disease. 2. Because of its fat solubility and easier penetration into the central nervous system, it has more adverse reactions in this system. Fatigue and dizziness account for 10%, depression accounts for 5%, and others include headaches, nightmares, insomnia, etc. Occasional hallucinations. 3. Digestive system: nausea, stomach pain, constipation [1%, diarrhea 5%, but not serious, rarely affect medication. 4. Others: shortness of breath, joint pain, itching, retroperitoneal fibrosis, deafness, eye pain, etc.

Precautions

1. Propranolol can delay the recovery of blood glucose levels after insulin administration, but this adverse reaction is less with selective β1-receptor blockers. It should be noted that when diabetic patients taking insulin add beta-blockers, their beta-receptor blocking effect often masks the symptoms of hypoglycemia such as palpitations, thereby delaying the timely detection of hypoglycemia. However, during treatment, the risk of selective β1-receptor blockers interfering with glucose metabolism or masking hypoglycemia is lower than that of non-selective β-receptor blockers. 2. If you want to discontinue treatment after long-term use of this product, you must gradually reduce the dosage and generally withdraw it within 7 to 10 days, and at least 3 days. In particular, sudden discontinuation of medication in patients with coronary heart disease may lead to worsening of the condition, resulting in angina pectoris, myocardial infarction or ventricular tachycardia. 3. There is no consensus on whether to stop using beta-blockers before major surgery. After beta-receptor blockade, the heart's response to reflex sympathetic excitation is reduced, which increases the risk of general anesthesia and surgery, but this can be reversed by dobutamine or isoproterenol. Nevertheless, it is best to stop using this drug in patients who are going to undergo general anesthesia, if possible 48 hours before anesthesia. 4. When used for pheochromocytoma, α-receptor blockers should be used first.