Magnolia officinalis nephrotoxicity is irreversible

Magnolia officinalis is the name of a traditional Chinese medicine. Traditional Chinese medicine has pharmacological effects and side effects. However, some friends believe that Magnolia officinalis is nephrotoxic and the damage is irreversible. The statement that Magnolia officinalis' nephrotoxicity is irreversible is actually not entirely correct, because Magnolia officinalis does not have obvious liver and kidney toxicity and is relatively mild. However, its application still needs to be guided by a regular Chinese medicine practitioner.

The side effects of traditional Chinese medicine can be reflected in two aspects. On the one hand, there are drugs that are considered to be hepatotoxic and nephrotoxic through modern pharmacological research. For example, Dioscorea bulbifera and raw Polygonum multiflorum are hepatotoxic, and aristolochic acid in Aristolochia australis is nephrotoxic. On the other hand, side effects are related to the therapeutic effects. For example, many doctors believe that if aconite, which is pungent, hot and toxic, is over-processed, its toxicity will decrease and its therapeutic effects will also decrease.

Magnolia officinalis does not have obvious liver and kidney toxicity, and there is no mention of obvious toxicity like aconite in relevant medical books, because it is relatively milder, but if used improperly, some side effects may occur. It is mainly a medicine for drying dampness and eliminating phlegm, as well as relieving qi and removing fullness, and it is pungent and warm. For patients with qi deficiency and body fluid deficiency, if Magnolia officinalis is used alone, it may lead to consumption of qi and damage to body fluid, which is its side effect. Therefore, its side effects are mainly caused by improper application. If it is used properly, no side effects will occur.

[Nature and flavor and meridians] Warm in nature, bitter and pungent in taste. It enters the spleen meridian, stomach meridian, lung meridian and large intestine meridian.

【Effects and functions】Drying away dampness and eliminating phlegm, relieving gas and eliminating fullness. It is a dampness-removing medicine.

[Clinical application] The dosage is 3 to 9 grams, decocted in water. It is used to treat dampness stagnation damaging the middle part of the body, abdominal distension, vomiting and diarrhea, food accumulation and qi stagnation, abdominal distension and constipation, and cough with phlegm and wheezing.

[Pharmacological Research] It has muscle relaxant effect; small doses can excite intestinal smooth muscle, while large doses have inhibitory effect; it has anti-ulcer effect, significant central nervous system inhibitory effect, blood pressure lowering, anti-pathogenic microorganism, anti-tumor effect; it also has anti-platelet and intracellular calcium flow inhibition effects.

[Chemical composition] Contains volatile oils, bioalkalis, saponins, tannins and trace amounts of niacin. It contains magnolol and magnolol, syringinol-4'-O-β-D-pyranoglucoside, magnolia lignans A, magnolia lignans B, magnolia lignans C, magnolia lignans D, magnolia lignans E, magnolia lignans F, magnolia lignans G, magnolia lignans H, magnolia lignans I, borneol-based magnolol and other ingredients.

[Contraindications] Use with caution in patients with Qi deficiency, loss of body fluid and blood deficiency, and pregnant women.

[Prescription Combinations] ① Treating worm accumulation: 6 grams each of Magnolia officinalis and Areca catechu, two black plums, decocted in water and taken orally. (The Complete Book of Baochi)

②For treating heart-spleen imbalance, weak kidney qi, or turbid stool and urine: 30g of Magnolia officinalis (prepared with ginger juice and slightly stir-fried), 3g of White Poria cocos. Mix the above ingredients together and add one bowl of water and one bowl of wine, boil until one bowl remains. Divide into two doses and take warm before meals. (Yingquan Powder from Puji Fang)

③For treating abdominal distension, pain and constipation: 240g Magnolia officinalis, 120g Rhubarb and 5 pieces of Citrus aurantium. Take the above three ingredients, add 1 dou 2 liters of water, boil the first two ingredients and take out 5 liters, then boil the rhubarb and take out 3 liters. Take one liter of the medicine warm, until it works. (Houpu Sanwu Decoction from Synopsis of the Golden Chamber)

④For treating vomiting and diarrhea in children, weak stomach and fright with phlegm: 30g of Magnolia officinalis, 3g of Pinellia ternata (soaked seven times, soaked in ginger juice for half a day, and dried in the sun). Soak with three liters of rice water for one hundred minutes, until all the water is gone. If it is not completely finished, add a little fire and boil until it is dry. Remove the Magnolia officinalis and only grind the Pinellia ternata. Take 1.5 grams each time, mixed with mint soup. (Houpu Powder from "Children's Medicine Formula")

⑤ Treat diarrhea due to stomach deficiency, especially effective for diarrhea in the elderly: 0.9 g of Aconitum (fried), 0.3 g each of Magnolia officinalis (fried with ginger), Licorice (fried), and Dried Ginger (fried). Take 3 grams each time, add three he of water and two slices of ginger, and boil until two he of water remains. Take while hot, and stop taking after two doses. (Jianpi San from Su Chen Liang Fang)