How to take prednisone tablets for children

Special attention must be paid to some medicines that children take after being sick, otherwise it will affect the growth of children. In severe cases, it may leave some sequelae. For example, drugs such as prednisone tablets also need attention. Although the side effects of this drug are relatively smaller, it cannot be ignored. It is necessary to find the correct way for children to take it, so that the normal therapeutic effect of this drug can be exerted without causing side effects.

⑴ Complementary alternative therapy: Oral, 5-10 mg per time, 10-60 mg per day, take 2/3 in the morning after getting up, and take 1/3 in the afternoon

⑵ Anti-inflammatory: Oral administration: 5-60 mg per day. The dosage for the course of treatment varies according to the condition.

⑶Autoimmune diseases : Oral, 40-60 mg per day, reduce as needed after the condition stabilizes

⑷ Allergic diseases : 20-40 mg per day, reduce by 5 mg every 1-2 days after symptoms are relieved

⑸ To prevent organ transplant rejection : generally start taking 100 mg orally daily 1 to 2 days before surgery, and change to 60 mg daily one week after surgery. ⑹ To treat acute leukemia, malignant tumors, etc.: take 60 to 80 mg orally daily and reduce the dosage after symptoms are relieved.

Prednisone structure diagram Prednisone has anti-inflammatory and anti-allergic effects, can inhibit the proliferation of connective tissue, reduce the permeability of capillary walls and cell membranes, reduce inflammatory exudation, and can inhibit the formation and release of histamine and other toxic substances. This product can also promote the decomposition of protein into sugar and reduce the utilization of glucose. This increases blood sugar and liver glycogen, which may lead to diabetes, while also increasing gastric juice secretion and appetite. When there is a serious toxic infection, it can be used in combination with a large amount of antibacterial drugs to have good cooling, anti-toxic, anti-inflammatory, anti-shock and symptom relief effects. Its water and sodium retention and potassium excretion effects are smaller than those of cortisone, and it has stronger anti-inflammatory and anti-allergic effects and fewer side effects, so it is more commonly used.

This product is white or off-white crystalline powder; odorless.

This product is slightly soluble in ethanol or chloroform and almost insoluble in water.

Specific rotation

Take this product, weigh it accurately, add dioxane to dissolve and quantitatively dilute to make a solution containing about 5 mg per 1 ml. Determine it according to the law (Appendix VI E of Part II of the 2010 edition of the Pharmacopoeia). The specific rotation is +167° to +175°.

Absorption coefficient

Take this product, weigh it accurately, dissolve it in ethanol and quantitatively dilute it to make a solution containing about 15μg per 1ml. Measure the absorbance at a wavelength of 240nm by UV-visible spectrophotometry (Appendix Ⅳ A of Part II of the 2010 edition of the Pharmacopoeia). The absorption coefficient () is 405-435.

Identification

(1) Take about 5 mg of this product and add 2 ml of sulfuric acid to dissolve it. Let it stand for 5 minutes and it will turn orange. Pour this solution into 10 ml of water and the solution will turn yellow and gradually turn blue-green.

(2) In the chromatogram recorded under the assay, the retention time of the major peak of the test solution should be consistent with the retention time of the major peak of the reference solution.