The absolute value of immature granulocytes is high

Those who have had a routine blood test in the hospital may know that a routine blood test mainly looks at the amount of red blood cells and hemoglobin, and the value of white blood cells, especially for pregnant women, to rule out anemia. However, high or low immature granulocytes have no clinical significance and are not a problem. Eat more nutritious foods during pregnancy and do a routine blood test once a month for observation. Now let’s understand why the absolute value of immature granulocytes is high!

1. Immature granulocytes are often mainly neutrophilic granulocytes and metamyelocytes. Granulocytes are named after their rich granules. The large number and density of granules are the main characteristics that distinguish them from monocytes and other cells.

2. Clinical significance: Primitive cells are rarely found in normal people's blood tests. Such cells may appear in the following situations: acute leukemia, myelofibrosis, myelodysplastic syndrome, myeloproliferative neoplasm, blast crisis of chronic leukemia or relapse of acute leukemia. The number of primitive cells in the blood smears of some patients will be significantly increased. Different numbers of granules and Ostwald bodies can be seen in the cytoplasm of these cells. The nuclear chromatin is loose, evenly colored, dark purple, and the nucleolus is obvious. Especially at the tail of the smear made with anticoagulated blood, it is easier to see piled or scattered primitive cells, which are usually accompanied by a history of anemia and thrombocytopenia.

3. Immature cells refer to morphologically identifiable cells in the various stages between the earliest cells (such as primitive granulocytes and primitive erythrocytes) and mature cells (such as segmented nuclear cells and erythrocytes) in the process of cell maturation. There should be no immature cells in normal peripheral blood smears (band cells should also be less than 5%), and cells at each stage in normal bone marrow should be within a certain range. When the hematopoietic system is diseased, changes in cytoplasm and quantity may occur, leading to changes in the proportion of cells at each stage that are characteristic of different diseases. These changes can help diagnose the disease, which is the significance of bone marrow blood cell classification.

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