Increased alkaliphilic granulocytes

In medical morphology, we all know that alkaliphils originate from bone marrow hematopoietic multipotent stem cells, differentiate and mature in the bone marrow, and then enter the bloodstream. The origin of mast cells is still controversial. Currently, the origin of human mast cells and the relationship between mast cells and alkaliphils remain unclear. So let’s learn more about alkaliphils!

The prominent feature of alkaliphilic granulocytes is that their cytoplasm contains coarse, unevenly distributed, blue-purple alkaliphilic granules. The granules of alkaliphilic granulocytes contain histamine, heparin, and allergic slow-reacting substances. White blood cells are a type of cell in the blood. When pathogens invade the human body, white blood cells can deform and pass through the capillary walls, concentrate at the site of invasion, surround and engulf the pathogens. If the number of white blood cells in your body is higher than normal, it is likely that your body has inflammation. Normal mature white blood cells in the human body can be divided into five categories: neutrophils, eosinophils, alkaliphils, lymphocytes and monocytes. Alkaliphils are a type of white blood cell that originate from hematopoietic pluripotent stem cells in the bone marrow and enter the bloodstream after differentiation and maturation in the bone marrow. The cell body of alkaline granulocytes is round, with a diameter of 10 to 12 μm. The purple-red cytoplasm contains a small number of coarse but unevenly sized and irregularly arranged black-blue alkaliphilic granules, which often cover the nuclear surface. The nucleus usually has 2 to 3 lobes, and because it is covered by granules, the nucleus is lighter in color. An increase in the number of alkaliphils is often seen in certain allergic diseases, certain blood diseases, certain malignant tumors and certain infectious diseases.

Alkaliphilic granulocytes originate from hematopoietic pluripotent stem cells in the bone marrow and enter the bloodstream after differentiation and maturation in the bone marrow. The normal value is a percentage of 0 to 0.01 or (0%-1%). The absolute value is 0 to 0.1109/L.

An increase in alkaliphilic granulocytes is seen in alkaliphilic leukemia (rare). Chronic myeloid leukemia is also often accompanied by an increase in alkaliphilic granulocytes. It can also be seen in myelofibrosis, poisoning by metals such as lead, mercury, silver, bismuth, poisoning by aniline, nitrobenzene, etc., hemolytic anemia, megaloblastic anemia, chronic hemolysis such as malignant tumors, and after splenectomy. Alkali neutropenia has no clinical significance because the reference value of alkali neutrophils in peripheral blood is very low. A slightly elevated alkaliphilic granulocyte count has no clinical significance.

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