What disease does frozen people have?

Frozen people are caused by a disease. When it comes to frozen people, many people may find it strange. What causes frozen people and what are the symptoms when the disease occurs. Judging from the literal meaning, the frozen man is like being frozen. In fact, freezing syndrome is a motor neuron disease. Because the patient's motor neurons are damaged, the patient's limbs, trunk, chest and abdominal muscles atrophy or become weak.

1. Causes

The cause of ALS remains unknown. 20% of cases may be related to heredity and gene defects. In addition, some environmental factors, such as heavy metal aluminum poisoning, may cause motor neuron damage. The main theories for the causes of motor neuron damage are:

1. Accumulation of neurotoxic substances. Glutamate accumulates between nerve cells, causing damage to nerve cells over time.

2. Free radicals damage nerve cell membranes.

3. The lack of nerve growth factor makes it impossible for nerve cells to continue to grow and develop.

2. Clinical manifestations

Early symptoms are mild and easily confused with other diseases. The patient may only feel some weakness, muscle twitching, fatigue and other symptoms, which gradually progress to systemic muscle atrophy and difficulty swallowing. Eventually respiratory failure occurs.

According to clinical symptoms, it can be roughly divided into two types:

1. Limb-onset type

The first symptoms are progressive atrophy and weakness of the muscles in the limbs, and finally respiratory failure.

2. Medullary onset type

Difficulty swallowing and speaking occur early, and quickly progress to respiratory failure.

Treatment

Make a diagnosis and differential diagnosis as early as possible, provide neuroprotection and supportive treatment as early as possible, such as Rirutai and other drugs, and maintain regular follow-up.

1. General treatment

Supportive therapy: symptomatic treatment and appropriate exercise. For example, pay attention to the functions of the respiratory tract and digestive tract. If there is a lot of saliva, a small amount of antihistamine can be given; if there is a lot of sputum, nebulizer inhalation and expectorants can be given; if depression occurs, antidepressant treatment can be given. In addition, you should turn yourself over more often to prevent pressure sores. If eating disorders occur, nasogastric feeding or percutaneous gastrostomy (PEG) is given.

2. Special treatments

Currently, the only drug internationally recognized and approved by the U.S. Food and Drug Administration (FDA) for the treatment of ALS is Rilutek, and it must be used as early as possible.

3. Respiratory therapy

When breathing becomes difficult, ordinary oxygen or a bi-directional positive airway pressure (BiBAP) machine can be used to assist breathing. If further respiratory failure occurs, a tracheotomy and the use of an artificial ventilator are required.

4. Research progress

Currently, the international community is trying to use neurotrophic factors, antioxidants such as vitamin E, vitamin C, creatine, CoQ10, etc. in combination with Rilutai to provide protective treatment for amyotrophic lateral sclerosis. However, the above treatment has yet to be confirmed by clinical trials. In addition, scientists are also conducting experimental research on gene therapy for this disease.