What is the disease of Anmeigao?

When transaminase levels are elevated, the first thing to consider is drinking or staying up late. In addition, viral infections, medications, and other wasting diseases, and liver problems can also cause elevated transaminase levels. Go to the hospital for medical treatment in time, have your liver function checked, and after finding out the cause, receive comprehensive treatment with drugs that protect liver function. The problem of elevated transaminase levels can be serious or minor, and some clinical manifestations are not obvious, so special attention needs to be paid. This article describes in detail the symptoms of high transaminase.

1. Symptoms

Some people do not experience symptoms of high transaminase levels, while others who experience symptoms of high transaminase levels may easily confuse them with symptoms of other diseases.

Common symptoms of high transaminase levels include fatigue, poor appetite, insomnia, low-grade fever, aversion to greasy food, nausea, vomiting, abdominal pain, diarrhea, and discomfort in the liver area. Mild symptoms include sweating, drowsiness, thirst, and eye fatigue when reading. In outpatient clinics, the most common symptom of hepatitis B patients is high transaminase. Therefore, hepatitis B patients should be familiar with these symptoms and go to the hospital for diagnosis and treatment in time when these symptoms occur.

In general, a mild increase in transaminase levels generally does not cause obvious symptoms, while patients with a larger increase in transaminase levels will experience symptoms such as fatigue, anorexia, nausea, vomiting, and abdominal distension. If the transaminase level rises to more than 500 units in a short period of time, you should consider whether you have acute hepatitis. If you receive timely treatment, acute hepatitis B can be completely cured.

2. Standards

There are two types of serum transaminases: alanine aminotransferase (ALT) which exists in the cytoplasm of liver cells, and aspartate aminotransferase (AST) which exists in the mitochondria of liver cells. Generally speaking, the normal range for both transaminases is 0-40 IU/L.

Elevated ALT activity indicates clinical onset, which often rises rapidly and then falls slowly. Alanine aminotransferase ALT is generally more than ten to dozens of times higher than the normal upper limit. ALT values ​​indicate the degree of inflammatory activity and are not significantly correlated with the management of tissue destruction.

Aspartate aminotransferase (AST) reflects the damage to the mitochondria of liver cells and can better explain the degree of damage to liver tissue. When the value of aspartate aminotransferase (AST) is higher than that of alanine aminotransferase (ALT), you should be alert to severe or chronic hepatitis.

We usually divide the increase of transaminase into three levels:

1. Less than 120 IU/L is called mild transaminase elevation;

2. Between 120-400 IU/L is called moderate transaminase elevation;

3. A level greater than 400 IU/L is called severe transaminase elevation.

If the transaminase exceeds the normal range, the doctor will recommend another re-examination. However, even if it is high, the condition cannot be simply judged by the degree of increase in the transaminase (ALT). Other indicators reflecting liver function (such as serum bilirubin, cholesterase, albumin, etc.) and the results of liver, gallbladder and spleen B-ultrasound examinations must be combined to comprehensively determine the degree of liver damage. Because in severe hepatitis, there may be fewer surviving liver cells and very little transaminase released into the blood, ALT decreases as the disease worsens, while serum bilirubin continues to rise, resulting in enzyme-bile dissociation. In some people with cirrhosis, liver function tests may be normal.