Neonatal jaundice with anemia

Most newborns will develop jaundice after birth. If the neonatal jaundice is accompanied by anemia, it is likely related to hemolytic jaundice. Neonatal hemolytic jaundice is divided into congenital and acquired. Regardless of whether it is congenital or acquired, the child must be actively treated. Parents should not be careless. Through regular treatment, neonatal jaundice can be cured, but you must actively cooperate with the doctor.

Causes of neonatal jaundice

When the baby is still a fetus, it relies on the placenta to supply blood and oxygen and is separated from the mother's body.

1. Excessive bilirubin production

(1) Excessive destruction of red blood cells: The fetus is in a low-oxygen environment in the mother's womb, and the red blood cells increase in compensation, but their lifespan is short. After birth, the blood oxygen content increases, and the excessive red blood cells are quickly destroyed.

(2) High heme oxygenase content: The content is high within 7 days after birth, and the potential for producing bilirubin is high.

2. Immature liver function

(1) Poor liver ability to absorb bilirubin: Insufficient levels of Y and Z proteins in liver cells result in insufficient liver absorption of bilirubin.

(2) Poor liver function of conjugating bilirubin: The content of glucuronyl transferase in the liver is low and its activity is insufficient, resulting in poor function of forming conjugated bilirubin.

(3) Poor liver excretion of bilirubin: Poor liver excretion of conjugated bilirubin can easily lead to cholestasis.

3. Characteristics of enterohepatic circulation: When a newborn is born, the normal intestinal flora has not yet been established and cannot convert the bilirubin entering the intestine into urobilinogen (fecal bilirubin).

Due to the above characteristics, the ability of newborns to absorb, bind and excrete bilirubin is significantly lower than that of adults, and bilirubin is produced more but excreted less, so jaundice is very likely to occur. Especially when the baby is suffering from hypoxia, delayed meconium excretion, delayed feeding, vomiting, dehydration, acidosis, cephalohematoma, etc., jaundice will be aggravated.