Is coagulopathy hereditary?

Consuming coagulopathy is a syndrome, not an independent disease. Under the influence of pathological effects, it will cause obvious changes in patients and may even infect the skin tissue of the body and begin to grow and develop in our blood. Whether this disease is hereditary or not still needs to be diagnosed to know.

Introduction

Dissipative coagulopathy (DIC) is a syndrome, not an independent disease. It is caused by various pathogenic factors, which lead to extensive fibrin deposition and platelet aggregation in capillaries, arterioles, and venules, forming extensive microthrombi. It leads to circulatory and other visceral dysfunction, consumptive coagulopathy, secondary fibrinolysis, and clinical manifestations such as shock, bleeding, embolism, and hemolysis. In the past, it was called defibrination and comsumptive coagulopathy. Recently, some people think that it is more appropriate to call it comsumptive thrombohemorrhagic disorders, but the most commonly used term is still disseminated intravascular coagulation.

Causes

There are many causes of DIC. According to data analysis, infection is the most common cause in my country, followed by malignant tumors (including acute leukemia), and the two together account for 2/3 of the causes. According to reports from abroad, malignant tumors, especially those with metastatic lesions, account for the largest proportion. Extensive tissue trauma, extracorporeal circulation, and obstetric accidents are also common causes of DIC. The causes of DIC involve factors related to the blood itself and factors other than the blood, which can be summarized as follows:

(I) Vascular endothelial damage and tissue trauma

1. Various serious bacterial infections (such as Staphylococcus aureus, Gram-negative bacteria, toxic dysentery, typhoid fever, etc.) can lead to DIC. The bacteria themselves and their toxins can damage tissues and vascular endothelial cells, activate factor XII kallikrein and bradykinin, and further activate the coagulation system. The latter also has a strong vasodilatory effect, which can dilate blood vessels and lower blood pressure, causing shock. The kinin system has a reinforcing effect on the coagulation process. Complement is also closely related to the coagulation, fibrinolysis and plasma kinin systems, and is also one of the factors of thrombosis. Recently, it has been discovered that leukocytes also play an important role in the mechanism of activating coagulation. They are affected by endotoxins and can release tissue factor, which, together with factor VII, can activate factor X to promote coagulation. Viral infections (such as hemorrhagic fever, severe Japanese encephalitis, etc.), malignant malaria, leptospirosis, rickettsial disease and rickettsial infection can also cause DIC. The mechanism of disease is roughly similar to that of bacterial infection. 2. Formation of antigen-antibody complex Various immune reactions and immune diseases can damage vascular endothelial cells, activate complement, and also cause platelet aggregation and release reactions, activating coagulation mechanisms, such as systemic lupus erythematosus, transplant rejection or other immune diseases.