Is Angelica dahurica poisonous?

Many people like to use Angelica dahurica to stew soup. Most people are familiar with Angelica dahurica. Since Angelica dahurica can be eaten, it means that it is non-toxic. In addition to being edible, Angelica dahurica also has high medicinal value. Angelica dahurica not only has the effects of beauty and anti-inflammatory, but also has the effects of antipyretic and analgesic. It is also very good for preventing cardiovascular diseases. You can use Angelica dahurica with confidence.

Is Angelica dahurica poisonous?

The toxic component in Angelica dahurica is imperatorin B. Small amounts of Angelica dahurica toxin have an excitatory effect on the animal's medullary vasomotor center, respiratory center, vagus nerve and spinal cord, and can cause increased blood pressure, slower pulse, deeper breathing, vomiting, etc. Large amounts can produce forced intermittent convulsions, followed by systemic paralysis.

Effects of Angelica dahurica

1. Beauty effects

It can dispel wind and relieve exterior symptoms, dispel cold and relieve pain, remove dampness and open the orifices, reduce swelling and discharge pus. It can improve human microcirculation, promote skin metabolism, eliminate excessive accumulation of pigments in tissues, remove facial spots and scars, and treat skin herpes, scabies, etc. "Shennong's Herbal Classic" points out that Angelica dahurica "grows skin, moisturizes the complexion, and can be used as facial cream." Whether it is the "Thousand Gold Facial Cream Recipe" or Empress Dowager Cixi's secret palace recipe for maintaining beauty, "Yurong Powder", Angelica dahurica is the main ingredient in making facial cream. It is said to be able to remove facial dark spots. Modern medicine has proven that Angelica dahurica has certain therapeutic effects on acne, blackheads and blackheads, and has unique therapeutic effects in whitening and removing spots, improving microcirculation and delaying skin aging.

2. Anti-inflammatory Effect

Oral administration of 4 g/kg of Angelica dahurica or Angelica dahurica decoction (1 g equivalent to 1 g of the raw drug) to mice significantly inhibited the inflammation of the mouse ears caused by xylene (P<0.01).

3. Antipyretic and analgesic effects

In an animal model of high fever created by subcutaneous injection of peptone into the back of white rabbits, 1g of Angelica dahurica or 15g/kg of Angelica dahurica decoction had a significant antipyretic effect. Oral administration of 8 g/kg Angelica dahurica or Angelica dahurica decoction significantly reduced the number of writhings induced by intraperitoneal injection of 1% acetic acid (0.1/kg) in mice, which was similar to the effect of 8 mg/kg aminopyrine, P<0.001. In the hot plate test on mice, those with a pain threshold within 30 minutes before administration were given 8g/kg of Angelica dahurica or Angelica dahurica by oral gavage. 60 minutes after administration, the pain threshold of Angelica dahurica and Angelica dahurica dahurica was significantly increased, P<0.001 and 0.01 compared with the saline group.

4. Antispasmodic effect

The bergamot lactone, zanthoxylum toxin and isoimperatorin B contained in it have obvious antispasmodic effect on rabbit ileum. Isoprugine can also increase the contractility of the rabbit uterus and the tension of the earthworm muscle. Scopolamine has an antispasmodic effect on uterine spasms in rats in vivo or in vitro induced by estrogen or barium chloride, with an ED50 of 0.09 mg/kg.

5. Effects on cardiovascular system

The isoimperatorin and quinceanine contained in this product have a blood pressure-lowering effect on cats. 50 mg/kg can reduce arterial pressure by 50%, and the effect lasts for 1.5 hours. The copolymer of isoimperatorin and N-vinylpyrrolidone can prolong the time of lowering arterial pressure in cats by 5-10 times. It can also reduce the contractile force of isolated frog hearts.

6. Antibacterial effect

Angelica dahurica decoction has inhibitory effects on Escherichia coli, Shigella dysenteriae, Proteus, Salmonella typhi, Salmonella paratyphi, Pseudomonas aeruginosa, Vibrio cholerae, and Mycobacterium tuberculosis. The oxypreparatatin contained in this product has antibacterial effect on 11 strains in vitro; imperatorin also has antibacterial effect on Zanthoxylum bungeanum toxin; the MIC of which against human Mycobacterium tuberculosis H37RV is 100mcg/ml. The water extract also has a certain inhibitory effect on pathogenic fungi such as Microspores of Ringworm.

7. Photosensitization

The furanocoumarin compounds such as bergamotol, zanthoxylum toxin, and isoimperatorin B contained in this product are photoactive substances. Once they enter the body and are exposed to sunlight or ultraviolet rays, they can cause solar dermatitis on the exposed skin, resulting in redness, swelling, increased pigmentation, and thickening of the skin. The photosensitizing activity of Zanthoxylum bungeanum is the strongest, followed by bergamotolone, and isoimperatorin B is the weakest. Photosensitizing substances can be used to treat vitiligo. Isoimperatorin is an active ingredient for the treatment of psoriasis, and its effectiveness has been clinically proven by erythema dose measurement.

8. Anti-cancer effect

Isoproteroside and angelicain have cytotoxic effects on Hela cells. The ED50 of isoimperatorin is 100 μg/ml.

9. Anti-radiation effect

Intraperitoneal injection of 1g/kg of Angelica dahurica methanol extract 5 minutes before X-ray irradiation has a protective effect on mouse skin damage.

10. Other functions

A small amount of Angelica dahurica can excite the animal's medullary vasomotor center, respiratory center, vagus nerve and spinal cord, and can increase blood pressure, slow the pulse, deepen breathing, and cause salivation and vomiting. Large amounts can cause tonic intermittent convulsions, followed by general paralysis.