Guillain-Barré syndrome

I believe that many people do not know the symptoms and treatments of Guillain-Barré syndrome, which will affect our treatment of Guillain-Barré syndrome. Guillain-Barré syndrome refers to the patient's cytomegalovirus infection, which affects the immune system and body fluids. Patients are advised to check their symptoms and receive timely treatment, because the disease can cause patients to experience breathing difficulties and other conditions.

Causes

Most patients have infections such as cytomegalovirus, Epstein-Barr virus or mycoplasma before the onset of the disease, but the cause of a few cases is unknown. The nature of this disease is still unclear, but it may be related to immune damage. Injection of patient serum into animal nerves can produce perivenous demyelinating lesions. In addition, C3b and immunoglobulin C (mainly IgG or IgM) are present in the patient's neural tissue. The above facts suggest that this disease may be related to humoral immunity. However, no antibodies to myelin proteins have been found in the blood of patients so far. One of the side effects of the H1N1 vaccine is the possibility of Guillain-Barré syndrome.

complication

Since patients with this disease often have to stay in bed for a long time, they are prone to complications such as aspiration pneumonia, sepsis, bedsores, deep vein thrombosis, pulmonary embolism, urinary retention, anxiety and depression. If the lesion involves the respiratory muscles, it can be fatal.

treat

1. Comprehensive treatment and care to keep the respiratory tract open and prevent secondary infection are the key to treatment. When the swallowing muscles and respiratory muscles are affected, coughing is weak and sputum discharge is difficult. If necessary, tracheotomy and ventilator-assisted breathing should be performed; strengthen care and turn the patient over more often to prevent pressure sores; patients with facial paralysis need to protect the cornea to prevent ulcers. Because this disease may be complicated by myocarditis, the heart condition should be closely monitored and the amount of fluid replacement should not be too large.

2. The use of hormones is controversial. It can be used for a short period of time in the early stage. The course of treatment should not be too long, generally about 1 month. Acute and severe cases can be treated with short-term shock therapy of hydrocortisone or dexamethasone.

3. High-dose immunoglobulin is administered intravenously. Should be used as soon as possible.

4. Plasma exchange therapy is a new treatment developed in recent years. It is initially considered effective but expensive.

5. Appropriate use of neurotrophic drugs such as coenzyme A, ATP, cytochrome C and other metabolic drugs, and vitamin B12 can also be used at the same time. Mi Kebao and others.