What is proteinuria?

There are many common diseases in life, and colds are the easiest to get. When the weather changes, people don't pay attention to keeping themselves warm, and they are very likely to get colds. This type of disease does not cause much harm to human health, and the treatment of such diseases is relatively simple, and simple medicines can be used. Only serious patients can choose infusion treatment. So what is proteinuria?

Many people don’t know much about what proteinuria is. It is also a symptom of disease. When such a problem occurs, it must be treated in time, otherwise it will cause great damage to one’s health and affect all aspects of one’s development.

What is proteinuria:

Proteinuria is a typical symptom of kidney disease, but the amount of urine protein leakage cannot reflect the severity of the kidney disease. In patients with mild chronic kidney disease, less urine protein leakage does not necessarily mean that the kidney pathological damage is mild; large amounts of proteinuria do not mean that the kidney pathological damage is severe. For example, in minimal change nephritis and mild mesangial proliferative nephritis, kidney lesions are mild, but the daily urine protein amount can reach several grams or even more than ten grams.

Generally speaking, proteinuria is divided into selective proteinuria and non-selective proteinuria. Selective proteinuria refers to the fact that protein electrophoresis is dominated by proteins with smaller molecular weight, such as albumin, α1 globulin, transferrin and γ globulin. Proteins with larger molecular weight, such as α2 globulin, fibrinogen, and β-lipoprotein, are present in lower amounts.

Patients with minimal change nephropathy, mild mesangial proliferative nephritis, some membranous nephropathy, early-stage membranous proliferative nephritis, and focal segmental sclerosing nephritis often present selective proteinuria, indicating that the damage to the glomerular filtration membrane is relatively mild.

Non-selective proteinuria refers to the simultaneous appearance of large and small molecular proteins in protein electrophoresis, indicating that the damage to the glomerular filtration membrane is relatively serious.

Through the above introduction, we have some understanding of what proteinuria is. It is a symptom of kidney disease. When such a problem occurs, it also depends on its severity. If it is very serious, the patient's body will also have obvious manifestations. Moreover, when proteinuria problems occur, human health is also seriously damaged.