Blocking antibody therapy

Blocking antibody therapy is mainly about the combination of some antibodies produced in the body with antigens on the surface of bacterial membranes, and at the same time producing some soluble antigens, that is, allergens, and some corresponding biological effects. For certain antibodies against tumors, it will have a certain effect. Therefore, the main focus of detection is on some common causes. It is also very necessary for patients with recurrent miscarriage to detect.

Detect some other types of diseases in life. However, blocking antibody treatment. Mainly to carry out some pregnancy period. Directly inject the blocking antibody. At the same time, in daily life, the main treatment is to use blocked antibodies.

(1) A type of antibody produced in the body that blocks the biological effect of T cell receptors on the antigen by binding to the corresponding antigen on the cell membrane surface or by binding to the corresponding soluble antigen (such as allergen). (2) Certain antibodies targeting tumor antigens can hinder effector cells from recognizing and attacking tumor cells by binding to the corresponding antigens, thus facilitating the continued growth of tumor cells. (3) Antibodies produced by the mother when she comes into contact with paternal antigens during pregnancy can bind to antigens on the surface of placental cells, thereby blocking the mother's cytotoxic T cells from launching an immune attack on the embryo, thereby protecting the fetus and maintaining pregnancy.

The types of blocking antibodies currently found are mainly the following:

1. Anti-warm B cell antibodies: Anti-HLA-D/DR antibodies on the surface of fetal B lymphocytes;

2. Anti-cold B cell antibodies: non-HLA cold B antibodies;

3. Anti-specific antibodies: Genetic antibodies against HLA-D/DR receptors on the surface of maternal helper T cells;

4. Anti-TLX antibody: It is an antibody against common antigens of villi and lymphocytes, which can block mixed lymphocyte reaction;

5. Anti-Fc receptor antibodies: non-cellular blocking antibodies that block Fc receptors on husband's B lymphocytes;

6. Anti-paternal complement-dependent antibodies (APCA).

Mechanism of Action In vitro studies have shown that during pregnancy the mother can produce sensitized T cells that can destroy germ cells. However, the killing function of sensitized T cells can be inhibited by specific antibodies. However, about 80%-90% of women with habitual abortion cannot detect such specific blocking antibodies, and uninhibited cytotoxic cells exist in their bodies. These cells can directly act on the embryo or indirectly damage the fetus or placenta by releasing inflammatory mediators, leading to miscarriage.

The above is the treatment of blocking antibodies, which is mainly carried out during pregnancy. Directly inject the blocking antibody. At the same time, in daily life, the main treatment is to use blocked antibodies. If that would produce if some other diseases can't produce some such antibodies. You need to go to the hospital for blocking antibody treatment, and you must receive timely treatment and care.