What causes gout?

Gout is one of the more common diseases in our human body. Gout is more common in the elderly in China, which should be related to their physical fitness. Gout is a disease that is quite harmful to the body, and there are usually many causes of gout, which makes it more difficult to treat. Although there are many medical treatments for gout, it is still difficult to cure gout.

There are many causes of gout, which are also related to the body's constitution. Gout is one of the more common diseases in the human body, and its incidence rate is relatively high. Gout has many symptoms, most commonly manifested by pain in joints throughout the body. So, let’s take a detailed look at the causes of gout.

Gout is a metabolic disease caused by abnormal purine metabolism leading to increased uric acid synthesis. Abnormal renal function can also cause an increase in uric acid levels due to a decrease in the kidney's uric acid clearance rate. Plasma saturation with uric acid results in the deposition of monosodium urate crystals in the relatively avascular tissues surrounding distal joints. The appearance of these crystals can lead to acute inflammatory synovitis in one or more joints. Gout is more common in men, and the big toe is the most commonly affected area, with 50% to 70% of initial onset occurring here. 90% of gout patients will have involvement of the first metatarsophalangeal joint at some time in their lifetime. Other areas of the foot that may be affected are the dorsum of the foot, the heel, and the ankle. In addition to affecting the joints, uric acid crystals can also be deposited under the skin in areas called tophi.

1. Genetics

The onset of gout is related to genetics, but it is rare for gout to be a clearly hereditary disease, accounting for only 1% to 2%. For example, self-destructive facial syndrome and glycogen storage disease type I. Common inheritance types include X-linked recessive inheritance, autosomal recessive inheritance and polygenic inheritance, among which the vast majority are polygenic inheritance.

2. Obesity

Obesity is also the most common risk factor for gout. Gout is often called "a disease of the rich". It is more common in middle-aged men over 40 years old who are relatively obese, especially those who do not like to exercise, eat more meat protein, and have excessive nutrition. It is often complicated by high blood lipids (high triglycerides) and hypertension. Therefore, in terms of the incidence of gout, obese people are more likely to suffer from it than thin people, those with excessive nutrition are more likely to suffer from it than those with normal nutrition, and the elderly are more likely to suffer from it than the young.

3. Irregular life

Some young people lead irregular lives and often stay up all night. This irregular lifestyle will disrupt the rhythm of the human body's "biological clock", cause metabolic disorders, aggravate the acidity of the body, and become a "favorite" of gout.

In addition to paying attention to their diet, gout patients can also drink more Yuhong acid-reducing ointment, which helps to excrete uric acid in the body, control and lower the level of uric acid in the body, and is very helpful in reducing gout attacks.

Therefore, through the detailed introduction of gout in the above article, most people should have a great understanding of the causes of gout. Through understanding, we will find that the causes of gout are generally: heredity, obesity, irregular life, etc. Knowing this will have a certain auxiliary effect on the future treatment of gout patients.