Causes of rheumatism

Rheumatism is a joint disease that can affect people's joint, muscle and bone health. In severe cases, it can cause difficulty in joint and muscle movement. It can harm people of different ages, especially teenagers and children. If not treated in time, it may even leave chronic heart disease. Do you know what causes rheumatism? Let's take a closer look.

In fact, there are many factors that can cause rheumatic disease. Therefore, no matter what age you are, you should pay attention to preventive health care. If you want better treatment, you need to prescribe the right medicine. This can reduce the harm caused by blind use of medicine.

1. Immune response: The body's stimulation of exogenous or endogenous antigens directly or through macrophage presentation activates the corresponding T cells, and some T cells produce a large number of various inflammatory cytokines, causing varying degrees of damage or destruction to various tissues and organs; some T cells then activate B cells to produce a large number of antibodies, which directly or combine with antigens to form immune complexes, causing damage or destruction to tissues or organs. In addition, monocyte chemoattractant proteins (such as MCP-1) produced by monocytes can also participate in the inflammatory response. Most rheumatic diseases, either due to exogenous antigens produced by infection or endogenous antigens produced in the body, can initiate or aggravate this autoimmune response, and a variety of antibodies may appear in the serum.

2. Genetic background: Recent studies have shown that some rheumatic diseases, especially connective tissue diseases, are closely related to genetics and patient susceptibility and disease expression, which has certain significance for early or atypical cases of the disease and prognosis; among them, HLA (human tissue leukocyte antigen) is the most important.

3. Infectious factors: According to research over the years, a variety of infectious factors, antigens or superantigens produced by microorganisms can directly or indirectly stimulate or initiate immune responses.

4. Endocrine factors: Studies have shown that the imbalance of estrogen and progesterone is related to the occurrence of various rheumatic diseases.

5. Environmental and physical factors: ultraviolet rays can induce SLE.

6. Others: Some drugs such as procainamide and some oral contraceptives can induce SLE and ANCA-positive vasculitis.

The above is an introduction to some of the causes of rheumatism. After understanding, we found that there are many factors that lead to rheumatism, and sometimes it is even caused by taking some medicines. Therefore, we should pay more attention to protection and prevention work to avoid the harm of these diseases.