Causes of Lupus Nephritis

The kidney is a very important organ in our human body. If there is a problem with our kidney, it will cause great harm to our entire body. Therefore, we must protect our kidneys in our daily lives. If there is a kidney disease, we should seek treatment immediately. Lupus nephritis is a type of kidney disease. We need to have a deeper understanding of lupus nephritis.

So what is lupus nephritis? What are the clinical manifestations of lupus nephritis? What is the cause of lupus nephritis? How can we prevent and treat lupus nephritis?

Lupus nephritis refers to a disease in which systemic lupus erythematosus (SLE) is combined with immune damage of different pathological types in both kidneys, accompanied by obvious clinical manifestations of renal damage. Its onset is related to immune abnormalities such as immune complex formation, immune cells and cytokines. In addition to the systemic manifestations of SLE, the main clinical manifestations are hematuria, proteinuria, renal insufficiency, etc. The pathological classification of lupus nephritis is of great value in determining disease activity and prognosis and formulating treatment plans. Treatment plans should be individualized according to the severity of the disease.

Lupus nephritis is a specific autoimmune disease involving multiple factors including genetics, sex hormones, environment, infection, drugs, and immune response. The interaction of the above-mentioned factors causes immune system disorders. The most important feature is the production of various autoantibodies such as antinuclear antibodies, which form immune complexes with antigens and are accompanied by immune abnormalities such as immune cells and cytokines. This is the common mechanism of multi-tissue and organ damage in SLE.

The pathogenesis of lupus nephritis may be related to the following factors:

① Circulating immune complexes are deposited in the kidneys;

② In situ immune complex formation;

③ Local complement activation;

④The direct effect of autoantibodies;

⑤T cell-mediated immune response, etc.

Above we introduced the importance of kidneys to our human body. If there is a problem with the kidneys, then problems will also arise in all aspects of our body. Therefore, we should protect our kidneys. Lupus nephritis is a type of kidney disease. The causes of lupus nephritis are introduced in detail above.