Treatment and maintenance of ichthyosis

Ichthyosis is a relatively common hereditary disease. This type of disease is relatively difficult to treat. In order to avoid further attacks of the disease, you should receive timely treatment from a doctor to suppress ichthyosis. Ichthyosis requires us to enhance our skin's drug resistance before receiving drug treatment to avoid other adverse symptoms. Genetic instability is the cause of ichthyosis.

For people with congenital ichthyosis, they should first maintain a good attitude, which will help with treatment. It is best to avoid eating and touching some daily irritants to avoid other adverse symptoms and injuries to ichthyosis.

1. Ichthyosis vulgaris

It is an autosomal dominant genetic disease with incomplete penetrance. It is currently believed that this is caused by mRNA instability and defects in post-transcriptional control mechanisms.

2. Sex-linked recessive ichthyosis

It is an X-chromosome-linked recessive inheritance. The absence or mutation of the steroid sulfatase gene (STS) causes the accumulation of cholesterol sulfate, which causes the stratum corneum cells to be tightly bound and unable to fall off normally, resulting in the formation of scales.

3. Lamellar ichthyosis

It is an autosomal recessive inheritance. The gene is located at multiple sites, including 2q33-35, 19p12-q12, and 14q11. The TGM1 gene undergoes mutation, deletion, or insertion, resulting in defects in cell adhesion and cell envelope protein cross-linking.

4. Epidermolytic hyperkeratotic ichthyosis

It is an autosomal dominant genetic disease. The pathogenic genes are related to mutations in the keratin 1 (K1) and keratin 10 (K10) genes, which lead to defects in the synthesis or degradation of keratin, affecting the normal arrangement and function of tension filaments in basal keratinocytes, and thus causing abnormal keratinization and epidermal loosening.

5. Congenital non-bullous ichthyosis-like erythroderma

It is an autosomal recessive inheritance caused by mutations in multiple genes such as the lipoxygenase 12 (R) (ALOX12B) gene and the lipoxygenase 3 (ALOXE3) gene.

6. Ichthyosis tortuosus

It is an autosomal recessive genetic disease caused by mutations in the serine protease inhibitor Kazal type 5 (SPINK5) gene on chromosome 5p32.

I believe that after reading this article we can learn in detail about some symptoms of ichthyosis. We must pay attention to these symptoms and related care methods. Learning more about treatment methods will help recover from the disease. The technology required for gene therapy is relatively difficult to achieve, so patients need to persist in treatment and be more patient in caring for the disease.