What are the anti-tumor pharmacology of traditional Chinese medicine?

For many patients with tumors, it is particularly painful, because if the tumor is not effectively treated, it will develop very quickly and even get out of control. Therefore, many patients with tumors want to fully understand the pharmacology of Chinese medicine in anti-tumor. In order for you to understand it as soon as possible, please take a comprehensive look at the detailed introduction below, hoping to help you control the tumor.

1. Interfering with the normal metabolism of cancer cells

Cancer cells are characterized by rapid growth and immaturity, and their nucleic acid metabolism is abnormally active. Many Chinese medicines have inhibitory or killing effects on cancer cells by interfering with nucleic acid metabolism. For example, berberine in Coptis chinensis and Phellodendron chinense can insert into the double helix structure of cancer cell DNA, preventing it from replicating and transcribing normally, thereby inhibiting the reproduction of cancer cells. Trillium gracile, camptothecin, Polygonum cuspidatum, Dalbergia odorifera, Solanum nigrum, Indigo naturalis, Ricinus communis, Psoralea corylifolia, etc. also have similar effects. The volatile oil in the stem bark and root bark of Acanthopanax rubra has an inhibitory effect on the growth of cultured human leukemia granulocytes and can inhibit the biosynthesis of their DNA at all stages. Indigo carmine, rubescens, scorpion, Stephania tetrandra, wolfberry, Brucea brucea, andrographolide, Polyporus umbellatus, and Zanthoxylum bungeana in the leaf of Isatis indigotica inhibit the synthesis of cancer cell RNA and the protein translation process, thereby inhibiting the biosynthesis of protein, thereby inhibiting the normal growth of cancer cells;

Indigo carmine can also induce lipid decomposition in chronic myeloid leukemia cells, increase the cholesterol/phospholipid ratio, reduce membrane lipid fluidity to restore membrane proteins to normal, promote membrane enzyme activity, carrier operation and various receptor functions, and increase protein biosynthesis, thereby inhibiting the growth and proliferation of malignant cells; it is already known that cAMP inhibits cell proliferation, cGMP promotes cell mitosis, and the cAMP level of tumor cells is significantly reduced. The higher the malignancy, the lower the cAMP level. Some anticancer drugs are effective by increasing the cAMP level. Licorice can increase the cAMP content of gastric mucosa and significantly increase the cAMP level of pyloric and cardiac mucosa. It can be used in compound prescriptions to improve the efficacy of treating gastric cancer; blister beetles inhibit the activity of cAMP phosphodiesterase and increase the cAMP level, and restore the cAMP/cGMP ratio.

Ginseng, asparagus, ophiopogon, Poria, Polyporus, coix seed, Atractylodes, red peony root, lily, white peony root, yam, pea, mushroom, and Brucea javanica can also increase the cAMP of tumor cells and have anti-cancer effects. Adding them into compound prescriptions can improve the efficacy.

The glycolysis of tumor cells is very active, and tumor cells mainly obtain energy from glycolysis. Rhubarb significantly inhibits the glycolysis-related enzyme system and has an anti-cancer effect; Salvia miltiorrhiza, Agrimony granadilla, etc. also have an inhibitory effect on the glycolysis of cancer cells; honeysuckle inhibits some enzymes in the metabolic process of cancer cells and has an anti-cancer effect.

Brucea javanica inhibits the activities of hexokinase, phosphofructokinase, malate dehydrogenase and succinate dehydrogenase in cancer cells, thereby inhibiting glycolysis and aerobic oxidation of sugars, thereby interfering with the energy metabolism of cancer cells and having an anti-cancer effect; ginsenosides can increase the glycogen content of cancer cells, inhibit glycolysis of cancer cells, inhibit the activity of pyruvate kinase and aldolase, reduce the activity of intracellular mucopolysaccharides and acid phosphatase, and inhibit the growth and division of cancer cells.

The indirubin molecules in the leaf of isatis can interact with the sialic acid on the cell surface of patients with chronic granulocytosis, as well as glycoproteins or glycolipids with receptor functions, reducing the negative charge of the membrane, thereby changing the permeability of the membrane to amino acids, sugars, nucleosides, inorganic salts, etc., causing disorders in the metabolism of substances in the cells and inhibiting the growth and proliferation of malignant cells;

Anemarrhena asphodeloides has an inhibitory effect on cancer cell membrane sodium pump. Blister blister inhibits and interferes with energy metabolism, inhibits catalase activity and reduces the level of carcinogenic toxins.

Poria cocos inhibits thymidine kinase, inhibits cell nuclear transport, inhibits the incorporation of nucleotides into RNA, reduces the synthesis of RNA, and can activate the complement of cancer tissue. The activated complement in the area near the tumor cells kills cancer cells by affecting macrophages, lymphocytes or other cells and humoral factors. Some ingredients can also directly enhance the body's immunity to improve the overall immune function and enhance resistance to cancer cells, and can also enhance the effect of anti-cancer chemicals. The alcohol preparation of whole scorpion inhibits the respiration of human liver cancer cells and has an anticancer effect on liver and colon cancer cells.

2. Destroy the structure of cancer cells and inhibit their growth

Arisaema and Atractylodes macrocephala condense cancer cells into clumps and destroy their normal structure; the plant lectins contained in ephedra, pokeweed, and locust can bind to cancer cells, thereby changing the membrane structure of cancer cells and having anti-cancer effects; asparagus is rich in protein, asparaginase, nucleic acid and folic acid, which can effectively control the abnormal growth of cancer cells and promote cell normalization. Asparagus can also improve the body's immunity. Other herbs with similar effects include angelica, chuanxiong, frankincense, myrrh, mulberry bark, mint, belamcanda chinensis, capillaris, lophatherum gracile, sophora flavescens, brucea javanica, ebony, terminalia chebula, bitter almond, aloe, borax, pearl powder, silkworm pupa, and wolfberry. Ginsenosides in red ginseng can cause cancer cells to redifferentiate and induce reversal to normal cells; garlic indirectly or directly damages the structure of chromosomes, the carriers of the genetic material of cancer cells, causing them to degenerate, thereby leading to degenerative changes in the nuclei of cancer cells and ultimately causing the death of cancer cells, and has an inhibitory effect on the formation of cancer cell colonies; Atractylodes macrocephala causes esophageal cancer cells to fall off, and the remaining small pieces of cancer cells have condensed nuclei, blurred nucleoli, and multiple vacuoles in the cytoplasm. Bupleurum causes necrosis and lysis of cancer cells. Musk causes obvious wrinkling and rupture of the cell membrane of cancer cells, uneven protrusions and fusion of the protoplasm.

3. Improve the physical and chemical properties of blood and prevent cancer cell metastasis

The blood of tumor patients tends to be in a hypercoagulable state of being thick, sticky, coagulated and aggregated, which is conducive to the metastasis of cancer cells. Many blood-activating and blood-stasis-removing drugs can make blood rheology parameters tend to normal, inhibit platelet aggregation, promote fibrinolysis, improve microcirculation, and thus help inhibit the metastasis of tumor cells, such as Chuanxiong, Leonurus japonicus, Red Peony Root, Safflower, Curcuma Atractylodes, Salvia miltiorrhiza, Curcuma longa, Sappan Wood, Millettia reticulata, etc. Researchers from the Faculty of Pharmacy at Osaka University and the Osaka Prefectural Center for Adult Diseases jointly discovered that ginsenosides in ginsenosides have the activity of inhibiting the infiltration of ascites cancer cells in mice. The researchers isolated 10 ginsenosides from white and red ginseng, which improved the inhibitory effect on infiltration.

What are the anti-tumor pharmacologies of traditional Chinese medicine? This is what many patients with tumors want to know in detail. The above is a detailed introduction to the anti-tumor pharmacologies of traditional Chinese medicine for many patients with tumors. Therefore, after fully understanding it, for many tumor patients, they can better control their tumors and improve their quality of life through the treatment of traditional Chinese medicine.