What causes uremia? Causes of uremia

In the early stages of uremia, patients often have symptoms such as dizziness, headache, fatigue, and decreased comprehension and memory. When uremia worsens, the patient's cardiovascular system may be affected and one needs to be vigilant. So what causes uremia?

One of the causes of uremia - diabetes

Diabetic patients have the characteristic of insufficient insulin secretion in the body, which leads to disorders in sugar and fat metabolism. Under high sugar conditions, glomerular endothelial cells are damaged, causing an intrarenal inflammatory reaction that affects the renal tubules and renal interstitium, leading to glomerular sclerosis, tubular and renal interstitial fibrosis, gradual loss of renal function, and ultimately causing uremia. Diabetic patients who fail to control their diabetes well and whose blood sugar control is unstable eventually have a 30% chance of developing end-stage uremia.

The second cause of uremia: kidney disease

Kidney disease is one of the main causes of uremia, and almost all patients with kidney disease will eventually suffer from uremia. Kidney disease, including uric acid kidney disease and polycystic kidney disease, may affect the kidneys and lead to renal failure. Among the diseases that cause uremia, chronic glomerulonephritis accounts for 55.7%.

The third cause of uremia - high blood pressure

Hypertension is one of the symptoms of uremia, and 15% of hypertensive patients will eventually suffer from uremia. What causes uremia? Long-term hypertension increases the pressure of the glomerular afferent arterioles. The high pressure within the glomerulus causes damage to the capillary endothelial cells and initiates the process of renal fibrosis. When renal function fails, the ischemic and hypoxic state will further aggravate hypertension. Once the vicious cycle of the two is started, uremia will occur in a certain period of time.

The fourth cause of uremia - chronic urinary tract obstruction

Due to long-term chronic urinary tract obstruction, normal urine cannot be excreted from the body in time, causing bilateral hydronephrosis and directly affecting renal function. If not treated in time, it will eventually damage renal function and cause uremia. Now with the improvement of medical conditions, the number of patients with uremia caused by urinary tract obstruction has decreased, but the renal dysfunction caused by this disease cannot be ignored.

The fifth cause of uremia - age factor

Age factors: With age, the structure and function of the kidneys will undergo significant degenerative changes. The body's reserve function will gradually weaken or even be lost. In the absence of additional burden, kidney function can meet the needs of human life activities, but it does not have the ability to cope with sudden injuries and diseases. Therefore, once the elderly encounter unexpected situations, it is easy to cause further damage to kidney function and develop uremia.

The sixth cause of uremia - toxic side effects of drugs

Toxic side effects of drugs: Studies have shown that approximately 25% of patients with renal failure are related to drug nephrotoxicity. People who frequently use painkillers are more likely to develop kidney problems.

The seventh cause of uremia - urinary system infection or urinary tract infection

Urinary tract infection or urinary tract infection is also one of the causes of uremia.

Uremia is called the "cancer" of kidney disease, which shows how harmful it is. When talking about uremia, people are often very afraid. Therefore, all kidney diseases must be taken seriously and treated promptly and in a standardized manner to prevent the occurrence of uremia.