What are the drugs for treating cerebral thrombosis? Have you used them?

The incidence of cerebral thrombosis is getting higher and higher. It often occurs in middle-aged and elderly people around 50 years old, and is more common in men than in women. Low molecular weight dextran can be used in the treatment process, which can reduce blood viscosity and improve microcirculation: 500 ml intravenous drip once a day, 8 to 10 days as a course of treatment. You can also use 706 generation plasma in the same way.

1. Relieve cerebral edema : For patients with large and severe infarction areas, dehydrating agents or diuretics can be used, but the amount should not be too large and the time should not be too long to prevent excessive dehydration from causing insufficient blood volume and electrolyte imbalance.

2. Improve microcirculation : Low molecular weight dextran can be used to reduce blood viscosity and improve microcirculation: 500 ml intravenous drip once a day, 8 to 10 days as a course of treatment. You can also use 706 generation plasma in the same way.

3. Dilute the blood : ① Isovolumetric hemodilution therapy: bloodletting and replacement of an equal amount of fluid at the same time; ② Hypervolumetric hemodilution therapy: intravenous injection of fluid that does not contain blood to achieve the purpose of volume expansion.

4. Thrombolysis: Thrombolytic therapy is best performed within 6 hours. ① Streptokinase: The initial dose is 500,000 to 1,000,000 U added to 100 ml of normal saline and dripped intravenously in half an hour. The maintenance dose is 600,000 U dissolved in 250 to 500 ml of glucose solution and dripped intravenously in 6 hours, 4 times/day, and the medication is maintained within 24 hours until the disease no longer progresses, but generally not more than 7 days. ② Urokinase: Use 10,000 to 30,000 Urokinase on the first day, added to glucose solution for intravenous drip in 2 to 3 times, 1 to 2 weeks as a course of treatment. Pay attention to bleeding tendency during medication. Patients who have used this medicine within 1 to 2 years should not use it again. It is contraindicated in patients with bleeding diathesis, hypofibrinogenemia, sepsis, cavitary tuberculosis, severe liver disease, endocarditis or recent bleeding. Allergy testing should be performed when using streptokinase.

5. Anticoagulation : used to prevent blood clot extension and the occurrence of new blood clots. During medication, close attention should also be paid to patients with bleeding tendency, bleeding diseases, active ulcers, severe liver and kidney diseases, infectious thrombosis and the elderly. ① Heparin: 12500-25000U, dissolved in 500-1000ml of 10% glucose solution, intravenous drip for 1-2 days, and then use according to the condition. ② Dicoumarol: Orally taken at the same time, 200-300 mg on the first day, and then maintained at 50-100 mg/d. The number of treatment days depends on the condition; ③ New anticoagulant: Orally taken, 20 mg on the first day, 16 mg on the second day, and then maintained at 4-8 mg/d. In addition, snake venom preparations, sodium alginate diester, etc. are also used clinically.