What are the functions of Nattokinase? Functions and usage of Nattokinase

Nattokinase, as the name suggests, is a substance decomposed from natto. It is a serine protease that has the effects of dissolving blood clots, softening blood vessels, and improving blood circulation in the human body. But too much is as bad as too little. Nattokinase should not be taken too much, otherwise it will bring a certain burden to the human body. So, what are the functions of nattokinase? The following will introduce the functions and taking methods of nattokinase.

1. Introduction

Nattokinase is a subtilisin kinase, a serine protease produced by Bacillus subtilisl natto during the natto fermentation process. It has the effects of dissolving blood clots, reducing blood viscosity, improving blood circulation, softening and increasing blood vessel elasticity, etc.

It was discovered in natto in 1980. It is composed of 275 amino acids in a fixed arrangement, with a molecular weight of 27724. It has the unique function of decomposing blood clots, and its active effect is expressed in the inherent unit FU.

2. Function

A notable function of nattokinase is its ability to dissolve blood clots. Mimugu F et al. determined the fibrinolytic activity of nattokinase using a blood clot dissolution assay and compared it with Plasmin. They found that the fibrinolytic activity of nattokinase was four times that of Plasmin. MiLsugu, F et al. When nattokinase was injected intravenously into a chemically induced thrombus model, significant thrombus dissolution was found, and it showed a higher fibrinolytic ability than plasmin and elastase. The above studies show that nattokinase

Nattokinase exhibits strong fibrinolytic activity both in vitro and in vivo. It can also activate plasminogen in the body, thereby increasing the amount of endogenous plasmin. In addition, after healthy people take nattokinase orally, the following effects occur:

1. Significantly shortened the dissolution time (ELT) of euglobulin;

2. Increased fibrinolytic activity in plasma;

3. The amount of t-PA in plasma increased. Due to the safety, stability and good thrombolytic effect of NK, it has the potential to be used as an oral agent for thrombosis treatment.

3. How to take

The normal daily maintenance amount of nattokinase should not be less than 2000FU. Therefore, medical nutrition experts recommend that the basic dosage of nattokinase for people taking it is as follows:

1. The daily intake of 2000FU is the dosage for normal or sub-healthy people to prevent cardiovascular and cerebrovascular diseases. Most people will experience physical reactions after taking it for about 7 days. They will feel more energetic and symptoms such as dry eyes will begin to improve. Sensitive people will react on the same day.

2. The daily intake of 2000FU-5000FU is the recommended dosage for patients with cardiovascular and cerebrovascular diseases. Most of the symptoms such as cold hands and feet, chest tightness, palpitations, limb numbness, dizziness, insomnia, etc. will gradually ease in about 15 days. Blood pressure and blood lipid indicators will gradually approach normal values ​​in about 2-3 months. When the indicators are normal, the dosage can be reduced to a healthy maintenance amount.

3. The daily intake of 5000FU-7000FU is the recommended dosage for patients with serious cardiovascular and cerebrovascular diseases. The symptoms will begin to ease around one month, and the alleviation will be obvious after three months. After the indicators improve, the dosage can be gradually reduced.

4. Chinese people do not have the habit of eating natto with meals, so the intake needs to be higher than the Japanese standard. A daily intake of nattokinase of more than 5000FU is more suitable for national prevention, health care, and conditioning. At the same time, the half-life of nattokinase is 8 hours[3], and its duration of action in the body is 8-12 hours. Taking it in divided doses in the morning and evening can work throughout the day, allowing the active ingredients to remain longer, making them easier to absorb and more effective.