Treatment of neurological canine distemper

Symptoms of canine distemper:

In the early stages of canine distemper, the dog's body temperature can be as high as 39.5 to 41 degrees Celsius, with loss of appetite, depression, watery discharge from the eyes and nose, sneezing, and diarrhea (a bit similar to a cold).

Within the next 2 to 14 days, the dog will have fever again, cough, purulent nasal discharge and purulent eye discharge. This is the middle stage of canine distemper.

At the same time, gastrointestinal diseases such as vomiting, diarrhea, and loss of appetite may occur. Highly depressed and sleepy. In the later stages of canine distemper, typical neurological symptoms will appear, such as foaming at the mouth and convulsions. It is difficult to treat at this time, but it is not impossible to treat (please do not give up any little life).

A little knowledge about colds: Sick dogs first have frequent runny nose, followed by sneezing and coughing. At this time, some sick dogs have tears, and their conjunctivae are flushed and slightly swollen. The sick dog's body temperature rises quickly, and the dog becomes depressed, suffers from chills and shivers, and has a decreased appetite or even complete loss of appetite. The rectal temperature may exceed 40°C.

The pathogenesis of canine distemper:

First of all, canine distemper is a plague-type disease for dogs. It is a highly contagious disease that can be transmitted through the air or food, but it is not a zoonosis so there is no need to be too nervous.

mechanism

CDV→upper respiratory tract mucosa→24h later, proliferate in macrophages→tonsils and bronchial lymph nodes→2-4 days, mononuclear C in bone marrow, thymus and spleen→4-6 days later, proliferate in Kupffer cells of stomach and small intestine lamina propria, mesenteric lymph nodes and liver→body temperature rises, leukocytopenia (mainly L)→8-9 days later, spread to epithelial C and neural tissue→14 days later, CDV is cleared from most tissues, but it may remain in neurons and skin. CDV → digestive tract → whole body (upper respiratory tract, etc.)

Features

A highly contagious, lethal infectious disease.

Canine distemper will most likely cause mixed bacterial infections during the course of the disease, so we cannot define canine distemper as just one type of bacteria.

Canine distemper virus is unstable at room temperature, especially to ultraviolet light, drying and

Sensitive to high temperatures above 50-60°C (122-140°F). The virus can survive for several weeks if kept frozen. It can survive for several weeks at 2~4°C, for several months at low temperature freezing, and for several years at freeze drying.

Most routine disinfections can kill CDV. Canine distemper virus is not very resistant and is sensitive to heat, dryness, ultraviolet light and organic solvents. It is easily killed by ultraviolet light, ether, formaldehyde and Lysol. Acidic or alkaline environments below pH 4.5 and above pH 9.0 can quickly inactivate it.

Therefore, the chance of infection due to frequent disinfection is very small.

Classification of canine distemper:

From what I have seen above, canine distemper is a very terrible disease.

It can be divided into the following

It can be mainly divided into five characteristic types: hyperacute, acute, gastrointestinal symptoms, neurological symptoms, and skin symptoms. The clinical symptoms are mainly limited to the upper respiratory tract, so coughing and runny nose will be obvious. The incubation period of canine distemper varies greatly depending on the source of infection. The incubation period from the same species is 3-6 days. The incubation period of infections originating from different species can sometimes be as long as 30 to 90 days.

Prevention and precautions of canine distemper:

Prevention of canine distemper 1. Vaccination

Dogs are vaccinated to prevent various diseases such as canine distemper and parvovirus. The formation of an antibody gives the dog the ability to resist the vaccine, but the vaccination is not 100% successful.

2. When buying a dog, choose a regular kennel or breeder, and don’t go to some unknown dog farms or some dog dealers, because many people bring back a truckload of goods from other places. As long as one of them is sick, the others will have a high infection rate. (Welcome to buy a puppy from us) It is protected from canine distemper and parvovirus.

3. Do not take puppies out and do not let them come into contact with other dogs. Puppies have poor resistance, and only by avoiding excessive contact with outside dogs can the probability of getting sick be greatly reduced.

4. Disinfect regularly to prevent bacteria from growing.

Treatment and medication for canine distemper:

Canine distemper treatment

1. Use large doses of canine distemper hyperimmune serum, canine distemper monoclonal antibodies and canine immunoglobulin G in the early stage of the disease. Canine distemper high immune serum: 5-10 ml for small dogs and 20-40 ml for large dogs, injected intramuscularly or intravenously, once a day for 3-5 consecutive days; 5-20 ml of canine distemper monoclonal antibody: injected subcutaneously, once a day for 3 consecutive days; canine immunoglobulin: 2 ml for small dogs and 4-6 ml for large dogs, twice a day for 3-5 consecutive days.

2. Use antiviral drugs. Polymyxin B: 0.5-1 mg for small dogs and 1-2 mg for large dogs, injected intramuscularly once a day for 3 to 5 consecutive days. Viravir: 50 mg for small dogs and 100 mg for large dogs, injected intramuscularly twice a day for 3 consecutive days.

3. Strengthen the heart and replenish fluids. For dogs with obvious symptoms of enteritis and severe vomiting, Ringer's solution 30-50 mg/kg body weight, 10% calcium gluconate 2-5 ml, and vitamin B6 50-100 mg can be mixed and injected intravenously.

4. Symptomatic treatment. If the dog has purulent rhinitis or severe nasal congestion, ephedrine, dexamethasone and kanamycin nasal drops can be used as a mixture of nasal drops; for dogs with dry cough or spasmodic cough, cough-relieving and expectorant drugs such as Ke Kuai Hao, aminophylline, chlorpheniramine, and licorice tablets can be used;

5. Supportive treatment. For dogs with a long course of illness and symptoms of weakness, 10u/o glucose 30-50 mg/kg body weight can be given intravenously, and 500 mg of vitamin C, 5-20 mg of adenosine triphosphate, 15 mg of cytochrome C5N, and 100-250 ml of compound amino acids can be added at the same time, which has a good effect on alleviating the condition and improving the overall condition.

Canine distemper is a very virulent virus. Even if some dogs survive with timely treatment, they may still suffer from sequelae of canine distemper, such as limb paralysis.