Symptoms and treatment of premature ovarian failure

There are many symptoms of premature ovarian failure. The most common ones are abnormal menstruation and abnormal leucorrhea, which can cause endocrine disorders in women, cause hair growth, cause changes in temperament, etc. When similar symptoms appear, you should go to the hospital for examination in time, and then take corresponding methods for treatment. The most common one is hormone therapy. Of course, there are also immunotherapy and surgical treatment, etc. You can choose the best method according to the specific condition.

Symptoms of premature ovarian failure

1. Reproductive organs

Patients with premature ovarian failure will experience persistent amenorrhea due to ovarian atrophy and symptoms of sexual organ atrophy, such as uterine atrophy, disappearance of vaginal folds, and vulvar atrophy. Premature ovarian failure is usually accompanied by a decrease in estrogen levels.

The patient's pubic and armpit hair will fall off, vaginal secretions will decrease, libido will be low, there will be pain during sexual intercourse, and occasionally intestinal discomfort. Most patients will have gastrointestinal discomfort in the early stages, such as abdominal distension, decreased appetite, weight loss, etc.

2. Irregular menstruation

Most patients with premature ovarian failure will have symptoms of infrequent and light menstruation, the uterus may atrophy and become smaller, and patients will also experience symptoms such as hot flashes, irritability and sweating.

3. Neurological symptoms

The nervous system of patients with premature ovarian failure will also have corresponding symptoms. Most patients have symptoms such as emotional instability, irritability, tension, insomnia, nightmares, and memory loss.

4. Cardiovascular symptoms

Patients with premature ovarian failure often have bouts of fever, or hot and cold, sweating, and sometimes dizziness. These symptoms may occur several or dozens of times a day, and often occur at night. Some women even experience symptoms such as stuffiness, shortness of breath, rapid heartbeat, and high blood pressure, which are caused by vascular dysfunction.

5. Other symptoms

Such as dry eyes, breast atrophy and sagging, loose and rough skin, osteoporosis, joint pain, genital inflammation, urinary incontinence, constipation, acne, pigmentation, etc.

Treatment of premature ovarian failure

1. Hormone therapy: It can improve symptoms such as facial flushing, menstrual disorders, vaginal dryness, etc. caused by decreased estrogen levels, but this treatment method lasts for a long time and must be used under the guidance of a professional gynecologist to continuously adjust the usage, dosage and route of the drug. In addition, regular physical examinations are required, preferably once a year.

Cyclic supplementation of estrogen and progesterone can avoid epithelial atrophy and calcium loss in the reproductive organs, and can protect the cardiovascular system and prevent changes in lipid metabolism. Oral estrogen can be started at any time, but it should be injected intramuscularly daily starting a few days after taking estrogen, and continuous injections are required.

2. Immunotherapy : Immunotherapy can be performed for those who are found to have antibody factors. Immunization by injection has become a more reliable treatment method.

3. Surgical treatment:

① For POF caused by ovarian vascular factors leading to ovarian nutrition deficiency, early diagnosis and early treatment should be carried out, and vascular bypass surgery should be performed as soon as possible before the ovarian function is completely lost, such as anastomosis of the ovarian artery with the inferior mesenteric artery or renal artery, to restore the ovarian blood supply and restore the vitality of the ovary;

② For those who are in the late stage of POF or have ovarian deficiency due to various reasons, ovarian transplantation has become a very successful treatment method.