Side effects of gonadotropin

Urinary gonadotropin is an injectable drug. When used together with chorionic gonadotropin, it has a good effect on promoting the secretion of gonadal hormones. It has a good therapeutic effect on primary or secondary amenorrhea, as well as female anovulation, or irregular menstruation, etc. It can have a good effect on infertility. You should also be aware of some precautions when using the drug, as the drug may cause some side effects.

Indications: Used in combination with chorionic gonadotropin, it is used to treat primary or secondary amenorrhea caused by insufficient secretion of gonadotropin, infertility caused by anovulatory oligomenorrhea, etc.

(1) Mainly ovarian hyperstimulation syndrome, manifested by lower abdominal discomfort or bloating, abdominal pain, nausea, vomiting, and ovarian enlargement. Severe cases can cause chest tightness, shortness of breath, decreased urine volume, pleural effusion, ascites, and even rupture and bleeding of follicular cysts. (2) If the ovaries suddenly enlarge after stimulation and multiple follicles develop, there may be ovarian torsion or ovarian cyst rupture, or even intra-abdominal blood accumulation. Generally, symptoms may worsen 3 to 10 days after HCG injection to induce ovulation. (3) The use of this product may often increase the risk of arterial embolism. (4) Multiple pregnancy and premature birth, etc.

Note: 1. The medication should be used under the guidance of an experienced gynecological endocrinologist. During medication, the following should be monitored: (1) Perform a comprehensive pelvic examination to understand the size of the ovaries, especially after the estrogen concentration begins to rise. Check daily until at least 2 weeks after the addition of chorionic gonadotropin; (2) Measuring basal body temperature every day will help understand ovulation; (3) Estrogen excretion should be measured by collecting urine or drawing blood every day to measure estrogen, starting from one week after taking this product. Start using choriotropin only 24 hours after the estrogen peak. If the estrogen level is too high, it is not advisable to give large amounts of HCG to avoid overstimulation of the ovaries; (4) Examination of cervical mucus can help understand the maturity of the follicles or whether ovulation has occurred; (5) Checking β-HCG to detect early pregnancy; (6) For patients with high LH levels, such as those with polycystic ovary syndrome, gonadotropin containing only 75U of FSH should be used. 2. Athletes should use with caution. 3. If severe ovarian hyperstimulation syndrome occurs, the medication should be discontinued immediately. 4. Use with caution in patients with asthma, heart disease, epilepsy, renal insufficiency, pituitary tumor or hypertrophy, thyroid or adrenal cortex hypofunction. 5. There have been reports of stillbirth and congenital malformations in pregnancies following combined treatment with this product and chorionic gonadotropin, but it has not been proven to be directly related to this product. 6. During the treatment with this product, when the diameter of the follicles reaches more than 20mm and the estrogen content reaches 100-150μg in 24 hours by ultrasound examination, gonadotropin can be injected. If the above indicators are exceeded and symptoms of ovarian hyperstimulation occur, the drug should be discontinued. 7. Discarded medicine packaging should not be discarded at will.