Enterovirus 71 negative

Enterovirus type 71 is what we commonly call the hand, foot and mouth vaccine. Under the current circumstances, this vaccine needs to be paid for by parents, and the decision to get the vaccine will be based on the parents' wishes. Many parents know the severity of hand, foot and mouth disease and the importance of enterovirus 71 vaccination, so many parents now choose to vaccinate their children because everyone wants their children to be healthy.

Enterovirus 71, abbreviated as EV71, is one of the main pathogens that cause hand, foot and mouth disease in infants and young children. A negative result means that the test result is normal.

Hand, foot and mouth disease symptoms

1. General symptoms

(1) Acute onset, with an incubation period of 3-5 days, and prodromal symptoms such as low-grade fever, general malaise, and abdominal pain. Scattered painful, millet- to mung-bean-sized blisters appear on the oral mucosa, and maculopapules and herpes appear on the hands and feet. Initially, they are maculopapules, which later turn into herpes. They are round or oval, about 3-7 mm in size, like the size of a grain of rice, smaller than the chickenpox rash, harder in texture, with a red halo around it, and less fluid in the blisters. Dot-like or flaky erosions can be seen under the grayish-white membrane. After the rash subsides, no scars or pigmentation are left. If there is a secondary infection, the skin damage will often be aggravated.

(2) In addition to the hands, feet and mouth, herpes can also appear on the buttocks and near the anus, and occasionally on the trunk and limbs. The rash dries up and disappears after a few days. The rash does not itch or cause pain.

(3) Some children may develop generalized papules and blisters, accompanied by aseptic meningitis, encephalitis, myocarditis, etc. It may be accompanied by symptoms such as cough, runny nose, loss of appetite, nausea, vomiting, and headache.

(4) Some cases only present with rash or herpetic pharyngitis. The whole course of the disease is about 5-10 days. Most cases can heal themselves with a good prognosis and no sequelae.

2. Symptoms of severe cases

In a few cases (especially those under 3 years old), encephalitis, encephalomyelitis, meningitis, pulmonary edema, circulatory failure, etc. may occur.

(1) Respiratory system manifestations include: shallow and difficult breathing, changes in respiratory rhythm, cyanosis of the lips, white, pink or bloody foamy fluid (sputum) in the mouth, and sputum sounds or moist rales in the lungs.

(2) Neurological manifestations include poor spirits, drowsiness, headache, vomiting, easy fright, limb tremors, weakness or paralysis; physical examination may reveal meningeal irritation and weakened or absent tendon reflexes; critical cases may present with frequent convulsions, coma, cerebral edema, and brain herniation.

(3) Circulatory system symptoms include: pale complexion, increased or decreased heart rate, shallow, rapid, weakened or even absent pulse, cold limbs, cyanosis of fingers and toes, and increased or decreased blood pressure.