Which chemotherapy drugs are best for intravesical instillation?

Intravesical instillation is a relatively common treatment method. Chemotherapy drugs are instilled into the bladder. This is a common method for treating bladder cancer. It is also a common auxiliary method for other urothelial cancers, such as ureteral cancer and renal pelvic cancer. This kind of instillation treatment can reduce the recurrence rate of bladder cancer. Instillation drugs are mainly divided into two categories. One is immune preparations, that is, BCG, and the other is chemotherapy drugs. There are many types of chemotherapy drugs.

Which chemotherapy drugs are best for intravesical instillation?

Intravesical instillation therapy is an important adjuvant treatment for bladder cancer and other urothelial cancers (renal pelvis cancer, ureteral cancer) after surgery. Instillation therapy can reduce the recurrence rate of bladder cancer, and some literature reports that it can reduce it by 14%.

There are many kinds of drugs for intravesical instillation therapy, which are mainly divided into two categories: one is BCG (an immune preparation), which is the first choice for intravesical treatment of carcinoma in situ and some highly dangerous superficial bladder cancers. The other category is chemotherapy drugs, which have many types and each hospital purchases different drugs. Commonly used ones in clinical practice include epirubicin, pirarubicin, mitomycin, hydroxycamptothecin, gemcitabine, etc., which are suitable for all superficial bladder cancers. Based on the currently published literature, it is not yet possible to evaluate which chemotherapy drug is more effective.

Intravesical chemotherapy is generally divided into two stages: once a week in the early stage for 4-8 weeks, and then changed to once a month for 6-12 months. Before instillation, the bladder should be emptied of urine as much as possible, and after instillation, urine should be retained for 1 hour before urinating.

What is intravesical chemotherapy?

Intravesical chemotherapy is a type of intracavitary chemotherapy. The doctor uses a catheter to inject chemotherapy drugs into the bladder. After a certain period of time, the patient will naturally empty his urine and the treatment is completed. The retention time of different drugs varies, but it should be noted that the retention time needs to be strictly in accordance with the instructions to achieve the best infusion effect of the drug.

Dietary suggestions:

Drink plenty of boiled water every day

Eat more vegetables and fruits, especially cabbage, cauliflower, radish, Chinese cabbage, rapeseed, shepherd's purse, kiwi fruit, banana, jujube and other fresh fruits

Eat less fatty foods. The more fatty foods you eat, the greater your risk of bladder cancer.

Eating foods rich in vitamin A and carrots can reduce the risk of cystitis