The significance of five items of myocardial enzyme spectrum

Some people may feel unfamiliar with myocardial enzyme spectrum, and indeed rarely hear of it in life. So what exactly is it, what is it used for, and what is its value and significance. Myocardial enzymes are mainly distributed in our body

Heart muscle and skeletal muscle. The myocardial enzyme spectrum contains five items, and these content indexes have their own use value. So today I will tell you about the significance of the five items in myocardial enzyme spectrum.

The normal values ​​of the five items of myocardial enzyme spectrum are: 1. Lactate dehydrogenase LDH: 100~240 IU/L; 2. Aspartate aminotransferase AST: 0~40 IU/L; 3. Creatine phosphokinase CK: 24~194 IU/L; 4. Creatine phosphokinase isoenzyme CK-MB: 0~25 IU/L; 5. Alanine aminotransferase ALT: 0~40 IU/L. Pay attention to whether you have infectious myocarditis, valvular heart disease, hyperthyroidism and other diseases. Sometimes autonomic nervous system dysfunction can also cause these symptoms. Quick-acting heart-saving pills are generally used to treat symptoms of insufficient blood supply caused by coronary heart disease. It is recommended to go to the hospital for an electrocardiogram first and then receive targeted treatment. It is recommended to go to the hospital for a comprehensive examination to identify the cause and facilitate treatment.

2What diseases require five myocardial enzyme tests?

The five items of myocardial enzyme spectrum are LDH, AST, CK and its isoenzyme, α-HBD.

Myocardial enzymes are generally distributed in cardiac muscles and skeletal muscles. In your case, they are all elevated. The patient is 9 years old. It may be myocarditis or rhabdomyolysis syndrome and muscle damage. Sometimes, an increase in myocardial enzymes may occur due to factors such as fever. Since some myocardial enzymes are not specific to myocardial cells, an increase in myocardial enzymes may occur when these organs are damaged.

Guidance:

It is recommended to check kidney function and troponin and other tests. If there is no myocarditis or myolysis, it is not a big deal and you should check regularly. If CK-MB is not too high, then it's fine. As long as the isoenzyme of creatine phosphokinase does not increase, there will be no problem.

4 Significance of five items of myocardial enzyme spectrum

When LDH is high, it can cause acute myocardial infarction, skeletal muscle damage, certain hepatitis, leukemia, cirrhosis, obstructive jaundice and malignant tumors. During a myocardial infarction, LDH will be high for 12-24 hours, reach a peak at 48-72 hours, and return to normal after 1-2 weeks. LDH in the late stage of malignant tumors and in the pleural and abdominal effusions caused by malignant tumors will be high. In patients with chronic glomerulonephritis, SLE, diabetic nephropathy, etc., urinary LDH can reach 3-6 times that of normal people. The urine contains a variety of substances that inhibit LDH activity, such as urea and small molecule peptides. Low pH can also inhibit LDH activity. The LDH level of patients with uremia is normal, and it will increase after dialysis because the urea level in the body is high. We can observe related diseases in the body through five tests of the myocardial enzyme spectrum.

HBD, LD, AST, CK and CK-MB together constitute the myocardial enzyme spectrum, which is of great significance for the diagnosis of myocardial infarction. The serum LD/HBD ratio of healthy adults is 1.3:1.6, but the serum HBD activity of patients with myocardial infarction increases and the LD/HBD ratio decreases to 0.8:1.2.

It is reported that patients in the acute stage of stroke and acute cerebrovascular disease have increased myocardial enzymes. The reason may be that the damage or destruction of brain tissue releases more enzymes, which leads to increased sympathetic nerve excitability, increased catecholamine secretion, and accumulation of catecholamines in myocardial tissue, resulting in secondary myocardial damage and increased myocardial enzyme values ​​in serum.

In addition, studies have shown that elevated myocardial enzymes can occur in many diseases that can cause damage to myocardial cells, skeletal muscle cells and other tissue cells, such as active rheumatic heart disease, viral myocarditis, dermatomyositis, nephritis, pneumonia, and some malignant tumors, leukemia, etc.