What are the symptoms of drug overdose?

As the saying goes, all medicines are poisonous, so try to take as little medicine as possible when it is not necessary. If you must take medicine, you must take it according to the doctor's instructions and do not act on your own, because overdose of medicine can cause irreparable damage. For example, some medicines can cause arthritis if taken too much. Today I will tell you the specific symptoms of overdose of medicines. Everyone must keep them in mind.

1. Drugs that can cause gouty arthritis

Diuretics, such as hydrochlorothiazide, furosemide, sodium urate, chlorthalidone, and acetazolamide; antirheumatic drugs, such as aspirin and phenylbutazone; antibiotics, such as penicillin, erythromycin, and chloramphenicol; antituberculosis drugs, such as isoniazid and pyrazinamide; lipid-lowering drugs, such as clofibrate and niacin; others such as insulin, levodopa, and epinephrine. These drugs often have unique effects in the treatment of corresponding diseases and play a "drug-to-disease" role, but they can affect the excretion of uric acid from the kidneys, thereby increasing the uric acid level in the blood and possibly causing urate crystals to appear in the tissues. If urate crystals are deposited in the joints, gouty arthritis can be induced, causing redness, swelling, and pain in the thumb joints, fingers, wrists, ankles, knees, and other joints.

2. Drugs that can cause septic arthritis

Adrenal cortical hormones such as prednisone and dexamethasone, when used in large doses or for a long time, can cause osteoporosis or aseptic necrosis of bone and lead to joint pain. What's more, it can significantly reduce the body's resistance and induce suppurative arthritis. Repeated injections of triamcinolone into the local joint cavity can directly damage the synovial membrane of the joint and cause arthritis, or cause suppurative arthritis due to insufficient disinfection during injection.

3. Drugs that can cause allergic arthritis

The biggest characteristic of penicillin is that it can cause a variety of allergic reactions, including rashes, increased eosinophils, and even anaphylactic shock that seriously threatens the patient's life. Among this series of allergic reactions, there is joint pain, and a few patients also have joint swelling and mild effusion. Joint pain can also occur when other drugs cause allergies. These allergic joint pains and arthritis caused by drugs will disappear when these drugs are stopped.

Tetanus antitoxin, diphtheria antitoxin, rabies serum, diphtheria, typhoid vaccines, etc. are all foreign proteins that can become antigens and cause allergic reactions, resulting in serum sickness and joint pain, muscle pain, fever, urticaria, etc. Joint pain usually occurs 1 to 4 days after taking the medication and often lasts for 1 week before disappearing. Even immunoglobulin G and placental globulin, which are mistakenly believed by some people to be tonics, may cause allergic joint pain after injection.