Adverse reactions of vasopressin

With the development of modern medical science, some drugs that are difficult to synthesize artificially can now be directly extracted from animals and used on the human body; for example, insulin and vasopressin, which will be discussed in this article, is a water-soluble component extracted from the pituitary gland behind the animal brain and can be used on the human body. All medicines are poisonous, let alone this kind of medicine extracted directly from animals. The following editor will introduce posterior pituitary hormone in detail.

Pharmacological Action

Pituitrin is a water-soluble component extracted from the posterior pituitary gland of pigs and cattle, which contains oxytocin and vasopressin (vasopressin is also called antidiuretic hormone). Oxytocin has a selective effect on uterine smooth muscle, and the intensity of its effect depends on the dose administered and the physiological state of the uterus. For a non-pregnant uterus, small doses can enhance the rhythmic contractions of the uterus; large doses can cause tonic contractions of the uterus. The pregnant uterus is insensitive in the early stages of pregnancy, but becomes more sensitive in the late stages of pregnancy. It has the strongest effect during labor, and its effect on the uterus gradually decreases after delivery. The characteristics of this product's effect on the uterus are: it has a strong contraction effect on the uterine body, but a smaller contraction effect on the cervix.

In addition, it can enhance the contraction of mammary smooth muscle and promote milk discharge. The antidiuretic contained in this product can reduce the amount of urine in animals, and also has the effect of constricting capillaries and causing high blood pressure.

Adverse Reactions

The medication may cause increased blood pressure, palpitations, chest tightness, angina pectoris, decreased urine volume, urgency to urinate, pale complexion, sweating, nausea, abdominal pain and other reactions. It may also cause angioedema, urticaria, bronchial asthma, and anaphylactic shock. The medication should be stopped immediately and symptomatic treatment should be given.

Precautions

Because it has a strong stimulating effect on the uterus and a pressor effect, it is not suitable for inducing or accelerating labor. If symptoms such as pale complexion, sweating, palpitations, chest tightness, abdominal pain, or anaphylactic shock occur after taking the medication, the medication should be stopped immediately. During intravenous infusion, attention should be paid to the drug concentration and drip rate, which is generally 20 drops per minute. Too fast a drip rate or intravenous push can easily cause abdominal pain or diarrhea.