How to take mannitol during colonoscopy

I believe everyone has encountered mannitol in life. In fact, the main medical function of mannitol is a diuretic. It can reduce intracranial pressure and has a very obvious effect on the treatment of kidney disease. Special attention should be paid to it in normal times. We need to have a thorough understanding of the usage and clinical application of mannitol.

Main Application

Mannitol is a good diuretic in medicine, reducing intracranial pressure, intraocular pressure, and treating kidney medicine, dehydration agent, sugar substitute, and is also used as an excipient for tablets and a thinner for solids and liquids. Mannitol injection, as a high osmotic antihypertensive drug, is a commonly used drug in clinical rescue, especially in the rescue of brain diseases. It has the characteristics of rapid blood pressure reduction and accurate efficacy required of drugs for reducing intracranial pressure. As an excipient for tablets, mannitol is non-hygroscopic, dries quickly, has good chemical stability, and has the characteristics of refreshing taste and good granulation properties. It is used in most tablets of anticancer drugs, antibiotics, antihistamines, vitamins, etc. In addition, it is also used in chewable tablets such as hangover sobering medicine and mouth freshener. In terms of food, this product has the lowest water absorption among sugars and sugar alcohols and has a refreshing sweet taste. It is used to prevent foods such as maltose, chewing gum, and rice cakes from sticking, and can be used as an anti-sticking powder for general pastries. It can also be used as a low-calorie, low-sugar sweetener for foods for diabetic patients, bodybuilding foods, etc. In industry, mannitol can be used in the plastics industry to make rosin esters and artificial glycerin resins, explosives, detonators (nitromannitol), etc. It is used for the determination of boron in chemical analysis and as a bacterial culture agent in biological testing. Although mannitol can be absorbed by the human gastrointestinal tract, it does not accumulate in the body. After being absorbed, part of it is metabolized in the body and the other part is excreted in the urine; dibromomannitol can be produced through the reaction with hydrobromic acid.

Used in the synthesis of resins and medicines; dehydrating drugs and diuretics. Treat cerebral edema and glaucoma, acute oliguria, prevent acute renal failure, and treat edema caused by nephrotic syndrome. The injection is contraindicated in patients with active intracranial hemorrhage (except for craniotomy).

Mannitol injection

Indications

(1) Tissue dehydration drugs. Used to treat cerebral edema caused by various reasons, reduce intracranial pressure and prevent brain herniation.

(2) Reduce intraocular pressure. It can effectively reduce intraocular pressure and is used when other intraocular pressure-lowering drugs are ineffective or before intraocular surgery.

(3) Osmotic diuretics. Used to differentiate oliguria caused by prerenal factors or acute renal failure. It can also be used to prevent acute tubular necrosis caused by various reasons.

(4) As an auxiliary diuretic measure to treat nephrotic syndrome and ascites due to cirrhosis, especially when accompanied by hypoproteinemia.

(5) In case of overdose of certain drugs or poisoning (such as barbiturates, lithium, salicylates and bromides), this drug can promote the excretion of the above substances and prevent nephrotoxicity.

(6) As an irrigation agent, it is used in transurethral prostatectomy.

(7) Preoperative bowel preparation.