Does hcg rise during ovulation?

The ovulation period is the time when the egg is discharged from the fallopian tube, and it is also the best time for pregnancy. However, hCG will not rise at this time, because hCG refers to gonadotropin, which is a hormone that will increase rapidly after conception. It is also an important indicator for us to check whether we are pregnant. When the concentration level of hCG reaches a certain height, it will remain stable and provide the fetus with a better living environment in the mother. However, too high hCG concentration can cause Down syndrome.

hCG values ​​over time

Human chorionic gonadotropin enters the maternal blood after fertilization and proliferates rapidly until the 8th week of pregnancy, then slowly decreases in concentration until the 18th to 20th week, and then remains stable. Generally, a level of at least 2.5 MoM of intact human chorionic gonadotropin is associated with Down syndrome. However, the actual average level of complete human chorionic gonadotropin in the maternal blood of DS patients is only 1.3MoM, which cannot clearly identify DS patients. The human chorionic gonadotropin-related molecules used for DS examination are free b-hCG and high sugar hCG (H-hCG).

The levels of human chorionic gonadotropin-related molecules are also related to the sex of the fetus. The levels of human chorionic gonadotropin in baby girls are significantly higher than those in baby boys.

Complete human chorionic gonadotropin is produced entirely by the syncytiotrophoblast of the placental chorion. Human chorionic gonadotropin is produced by trophoblast transitional cells and syncytial cells. Human chorionic gonadotropin begins to be secreted 10-14 days after conception.

Function of hCG

1. It has the functions of FSH and LH, maintains the life of the menstrual corpus luteum, and enlarges the menstrual corpus luteum into the corpus luteum of pregnancy;

2. Promote the aromatization of androgens into estrogen and stimulate the formation of progesterone;

3. Inhibit the stimulation of plant lectins on lymphocytes. Human chorionic gonadotropin can be adsorbed on the surface of trophoblast cells to prevent embryonic trophoblast cells from being attacked by maternal lymphocytes;

4. It has LH-like function. Before the fetal pituitary gland secretes LH, it stimulates the fetal testicles to secrete testosterone to promote male sexual differentiation. It can also promote gonadal development, stimulate the activity of interstitial cells in the testicles in men, and increase the secretion of androgen (testosterone). It is of great significance for the treatment of male patients with combined pituitary deficiency. It can not only promote gonadal development and the secretion of male hormones, but also promote the development of secondary sexual characteristics.

5. It can bind to the TSH receptor of maternal thyroid cells and stimulate thyroid activity.

Can high hcg be a malformation?

1. If the hCG value is high during pregnancy, it may be due to the following reasons:

1. The time of the last menstrual period may be miscalculated, resulting in a discrepancy between the actual gestational age and the estimated gestational age.

2. It may be twins or multiple births, because the value of multiple pregnancy is higher than that of single pregnancy.

If the doctor confirms that it is one of the above two situations, then the pregnant woman does not need to worry.

3. It may be an abnormal pregnancy - hydatidiform mole. The blood hCG value is usually higher than the normal pregnancy value of the corresponding gestational week.

If a hydatidiform mole is confirmed, the patient needs to be hospitalized immediately.

4. On the Down syndrome screening checklist, the reference range of the median multiple of β-hCG is 0-2.5. If it is higher than this value, it will have an adverse effect on the safety of mother and child during pregnancy. For example, pregnant women are more likely to suffer from gestational hypertension. This needs to be judged based on the actual individual situation. Some pregnant women have received hCG injections to preserve the fetus in early pregnancy, so there is a possibility that the hCG values ​​will be high during the Down syndrome screening.