Treatment of gastric ulcer

Everyone should know about gastric ulcer. I believe that many people are suffering from this disease. It is a chronic disease and it is easy to relapse after a period of treatment. This is also very painful for patients. There are many methods for the treatment of gastric ulcer, including traditional Chinese medicine, Western medicine, and common surgical treatment, which is also very effective. I hope patients can learn more about it.

Gastric ulcer is a very painful disease and must be treated actively. Western medicine treatment is a very common treatment for gastric ulcer. There are many types of Western medicine treatment, including general treatment, drug treatment, and surgical treatment. Different treatment methods are suitable for patients with different conditions.

Western medicine treatment of gastric ulcer

1. General treatment

With the study of the pathogenesis of gastric ulcer, general treatment has become increasingly important. Among them, regulating diet and lifestyle is an important aspect. This includes stopping smoking, drinking, chewing betel nuts and other highly irritating foods, and eating three meals regularly and in moderation. For patients with stressful lives, work and study, it is necessary to pay attention to rest and combine work with rest, or even rest in bed.

2. Medication

According to the pathogenesis of gastric ulcer and the characteristics of drug action, it can be divided into four categories: antacid preparations, various parietal cell receptor blockers, mucosal protectants and anti-Helicobacter pylori antibiotics.

(1) Antacids: mainly sodium bicarbonate, aluminum hydroxide and many compound preparations such as Metoprolol and Metoprolol. These drugs have a certain effect in relieving symptoms.

(2) Receptor blockers:

(3) Mucosal protectants: This type of drug mainly protects the gastric and duodenal mucosa by increasing mucosal thickness and promoting mucus and HC03- secretion. Includes prostaglandins and topical preparations.

① Prostaglandins: promote the secretion of gastric mucus and inhibit the secretion of gastric acid. The ulcer cure rate is 80% within 6 weeks. It can also effectively prevent stress ulcers and bleeding. Includes the following: Misoprostol: 200 mg/time, 4 times/d. Enprostil: 35 μg/time, 4 times/d. Ababaprost: 100 μg/time, 4 times/d.

②Topical preparations: including the following drugs. Sucralfate: It is an alkaline aluminum salt of sulfated sucrose. It can release sulfated sucrose and aluminum hydroxide in water, which have the effects of inhibiting pepsin activity and neutralizing gastric acid respectively. Its molecules disintegrate into active negatively charged particles in an acidic environment, forming a sticky, paste-like complex. It selectively adheres to the ulcer base to form a protective barrier. In addition, it also stimulates HCO3- and mucus secretion. Usage: 1g/time, 4 times/d. Bismuth tripotassium bismuth complex (De-Nol) is a colloidal bismuth citrate salt with a mechanism of action similar to that of sucralfate. At the same time, this drug is a bactericide for Vibrio pylori, so it is widely used clinically.

(4) Anti-Helicobacter pylori drugs: Recent studies have shown that gastritis and gastroduodenal ulcers are closely related to Helicobacter pylori infection. Relevant data show that the cumulative risk of HP infection developing into peptic ulcer is 15% to 20%. After successful elimination of Helicobacter pylori (Hp), gastritis and ulcers are also cured. After follow-up for more than one year, the recurrence rate drops from 80% to 20%. Commonly used drugs are:

① Bismuth agents: such as tripotassium dicitron complex bismuth, colloidal pectin bismuth, etc.

②Tetracycline: 250mg~500mg/time, 3 times/day. Amoxicillin can also be used instead of tetracycline, such as in children.

③Metronidazole: 200-500 mg/time, 3 times/day. Foreign countries advocate the use of three drugs in combination for 2 consecutive weeks, and the HP clearance rate can reach 80% to 90%.

In addition, there are other drug treatments for gastric ulcers, such as somatostatin octapeptide, which generally inhibits the secretion of digestive juices in the digestive system. It has certain therapeutic effects on gastric ulcer bleeding and stress ulcer bleeding. This drug is also widely used in the treatment of diseases such as pancreatitis, pancreatic fistula, intestinal fistula, and portal hypertension.

3. Surgery

With the development of medicine and the role of drugs in the treatment of peptic ulcer, there have been great changes in the treatment of peptic ulcer. Currently used anti-ulcer drugs can heal 75% of ulcers within 4 weeks and 85% to 95% of ulcers within 8 weeks. The relapse rate after drug treatment is also decreasing. Moreover, a large amount of clinical data shows that elective surgeries are decreasing, while the proportion of emergency surgeries (especially those due to perforation and massive bleeding) is increasing. However, the indications for surgical treatment of gastric ulcers should be appropriately relaxed compared with those for surgical treatment of duodenal ulcers.

For the treatment of gastric ulcer, patients must treat it correctly. They should be in good condition when suffering from this disease, not frowning every day, and go to a good hospital for treatment in time. At the same time, they should pay attention to scientific diet in daily life, develop good work and rest habits, and avoid the recurrence of gastric ulcer. Everyone should know more about the common sense of gastric ulcer treatment.