What is the cause of high triglycerides? Be careful, it may be a disease!

High triglycerides are hypertriglyceridemia, and there are two main types of high triglycerides: secondary hypertriglyceridemia and primary hypertriglyceridemia. As for what causes high triglycerides, this condition may be caused by some disease factors and is more common in diabetic patients.

1. Diabetes:

According to the simplest classification method, it can be divided into insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM). The pathogenesis of hypertriglyceridemia is different in different types of diabetes. In patients with uncontrolled IDDM and ketosis, severe insulin deficiency is often accompanied by significant hypertriglyceridemia. This is due to the inhibition of lipoprotein lipase activity, which causes CM to accumulate in plasma. Generally, the insulin level of NIDDM patients is higher than that of IDDM patients. The hyperinsulinemia of NIDDM patients often causes excessive secretion of endogenous insulin to compensate for the original insulin resistance. This severe hyperinsulinemia causes increased triglyceride levels due to its significantly weakened activation effect on lipoprotein lipase.

2. Kidney disease:

Although the most common dyslipidemia associated with renal diseases such as nephrotic syndrome is hypercholesterolemia, hypertriglyceridemia is also not uncommon. The mechanism of dyslipidemia in kidney disease is mainly due to the increased synthesis of VLDL and LDL, but some people also believe that it may be related to the slower metabolism of these lipoproteins.

3. Hypothyroidism:

This disease is often accompanied by elevated plasma triglyceride concentrations. This is mainly due to the delayed clearance of VLDL caused by the reduction of hepatic triglyceride enzymes, and may also be accompanied by the presence of intermediate density lipoprotein (IDL).

Density lipoprotien, IDL) is overproduced.

(iv) Obesity: In obese patients, the production of VLDL increases significantly due to excessive synthesis of apolipoprotein B by the liver. In addition, obesity often coexists with other metabolic diseases. People with abdominal obesity have more obvious increases in triglycerides than those with hip obesity.

(V) Fat malnutrition:

It is a rare metabolic disease characterized by fat loss in a specific area of ​​the body accompanied by hypertriglyceridemia. Its pathogenesis is still unclear. It may be due to a decrease in lipoprotein lipase in adipose tissue or an increase in VLDL synthesis in the liver.

(VI) Hyperuricemia:

About 80% of gout patients have hypertriglyceridemia, and conversely, 80% of patients with hypertriglyceridemia also have hyperuricemia. This relationship is also influenced by environmental factors, such as excessive intake of simple sugars, heavy drinking, and use of thiazide drugs.