What are the effective treatments for chronic urticaria?

After suffering from urticaria, most people suffer from acute urticaria, but some cases of urticaria are also chronic, so everyone should be vigilant about urticaria. Generally, when treating chronic urticaria, we must first find the cause and carry out anti-allergic and anti-inflammatory treatments. In a season when urticaria is prone to occur, take good preventive measures against urticaria.

Treatment strategy

Find the cause of the disease, avoid inducing factors, and actively carry out anti-allergic and anti-inflammatory treatments.

Drug treatment

1. Antihistamines: Most patients can achieve satisfactory results after treatment with antihistamines. For stubborn and intractable urticaria, the dosage can be increased or combined medication can be used. 2. Drugs that inhibit mast cell degranulation. Ketotifen inhibits mast cell degranulation and prevents the release of inflammatory mediators by increasing the concentration of cAMP in the body. Its inhibitory effect is stronger and faster than that of sodium cromoglycate and can be taken orally. Tranilast reduces histamine release by stabilizing mast cell membranes. 3. Glucocorticoids are particularly suitable for acute urticaria, serum sickness urticaria, pressure urticaria and autoimmune urticaria. Commonly used drugs include prednisone and Diprosone. In emergency situations, use hydrocortisone, dexamethasone, or methylprednisolone intravenously. 4. Immunosuppressants: When patients with chronic urticaria have an autoimmune basis, the disease recurs, and the above treatments are ineffective, immunosuppressants can be used. Cyclosporine has a good therapeutic effect. Azathioprine, cyclophosphamide, methotrexate and immunoglobulin can all be tried. Tripterygium wilfordii also has a certain therapeutic effect. 5. Non-specific anti-allergic therapy and other therapies, such as 10% calcium gluconate injection, 10% sodium thiosulfate, 6-aminocaproic acid, reserpine, aminophylline, etc. can be tried. 6. If urticaria is caused by infection, anti-infection drugs should be used for treatment.

Other treatments

1. Find the cause of the disease, ask about the medical history in detail, strive to find the cause of the disease, understand whether there is a family history of the disease, whether there is a history of acute or chronic infection, medication history, occupation, lifestyle habits and environmental changes, etc. Check blood, urine and stool routinely, and perform skin allergen test, ice test, acetylcholine skin test, serum IgE test and serum complement test as needed. Some patients need to undergo tests for HBV-DNA, thyroid antibodies, malignant tumors, etc. 2. Avoid inducing factors. For cold urticaria, pay attention to keeping warm. For acetylcholine urticaria, reduce exercise, sweating and mood swings. For contact urticaria, reduce the chance of contact with allergens.